CXT-MAIN: a software package for determination of the analytical form of the pharmacokinetic system weighting function

Computer Methods and Programs in Biomedicine
L Dedík, M Durisová

Abstract

A new procedure specific for the determination of the analytical form of the model weighting function of a complex multicomponent pharmacokinetic system with or without a shunt and time delays is described. The procedure is based on the theory of linear dynamic systems and on a circulatory pharmacokinetic model of the living body. The model transfer function of the system under study was obtained by the frequency response method in the form of the ratio of two frequency dependent polynomials. Subsequently, the technique of the partial fraction inversion was employed to determine the analytical form of the model weighting function. Two examples from bioavailability studies in pharmacokinetics are given. The first example presents two estimates of the model weighting function of a pharmacokinetic system obtained by the new procedure and by a polyexponential deconvolution method. To compare these results, two models of the measured system output were determined using the two estimates of the model weighting function, the actual system input and a convolution method. The model weighting function obtained by the new procedure yielded a better model approximation of the output data than that obtained by the polyexponential deconvolut...Continue Reading

References

Jun 1, 1984·IEEE Transactions on Bio-medical Engineering·Y Plusquellec, L Bousquet
Jul 1, 1982·Journal of Clinical Pharmacology·K W HallA R DiSanto
Jun 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·H Boxenbaum
Oct 1, 1980·Journal of Pharmacokinetics and Biopharmaceutics·P Veng-Pedersen
May 1, 1995·International Journal of Bio-medical Computing·L Dedík, M Durisová
Aug 1, 1994·Journal of Pharmacokinetics and Biopharmaceutics·L Dedík, M Durisová
Nov 1, 1995·Bulletin of Mathematical Biology·M DurisováM Balan

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Citations

Jan 1, 1996·Biopolymers·A LombardiV Pavone
Nov 13, 2004·European Journal of Drug Metabolism and Pharmacokinetics·Jovan Popović
Jun 29, 2002·Computer Methods and Programs in Biomedicine·Ladislav Dedík, Mária Durisová
Feb 3, 2007·Diabetes Research and Clinical Practice·Ladislav DedíkMartina Tvrdonová
Jun 10, 2005·Basic & Clinical Pharmacology & Toxicology·Sage W Wiener, Robert S Hoffman
May 9, 2012·TheScientificWorldJournal·Mária Durišová
Apr 28, 2005·Basic & Clinical Pharmacology & Toxicology·Mária Durisová, Ladislav Dedík

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