Cyanidin-3-glucoside enhances mitochondrial function and biogenesis in a human hepatocyte cell line

Cytotechnology
Rashad MogalliNobuhiro Ohkohchi

Abstract

Mitochondrial dysfunction has been identified as one of the primary factors contributing to liver diseases. Pathways that control mitochondrial biogenesis are potential therapeutic targets for the amelioration of hepatocyte dysfunction and liver disease. Research on natural pharmacological agents that ameliorate liver diseases has intensified over the last two decades. Cyanidin-3-glucoside (Cy3g), a dietary flavonoid compound extracted from a wide variety of fruits and vegetables, reportedly has several beneficial health effects. In this study, we used an adult human hepatoma cell line (HuH7) to investigate the effects of the Cy3g polyphenolic compound on mitochondrial function and biogenesis in vitro. An increase in intracellular mitochondrial reductase levels was observed after treatment with Cy3g, but cytotoxicity was not induced. In addition, mitochondrial membrane potential and ATP production were increased following Cy3g treatment. Cy3g treatment also resulted in a dose- and time-dependent upregulation of the gene expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), a transcription factor considered a master regulator of mitochondrial biogenesis and metabolism. Additionally, the exp...Continue Reading

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Citations

Nov 14, 2019·Critical Reviews in Food Science and Nutrition·Vidmantas BendokasJulius Liobikas
Apr 1, 2021·Journal of Drug Targeting·Li XiangYuping Chen
May 28, 2019·Toxicon : Official Journal of the International Society on Toxinology·Chandrashekhar SinghJasmeet Singh
Aug 3, 2021·Oxidative Medicine and Cellular Longevity·Leila ChodariAziz Eftekhari

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Methods Mentioned

BETA
PCA
PCR

Software Mentioned

Cytosoft

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