Cyanidin-3-glucoside inhibits inflammatory activities in human fibroblast-like synoviocytes and in mice with collagen-induced arthritis

Clinical and Experimental Pharmacology & Physiology
Yan Sun, Lingling Li

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint tissue inflammation. Cyanidin-3-glucoside (C3G) is a major component in the flavonoid family and has shown anti-inflammatory, anti-oxidant and anti-tumour activity. In this study, we investigated the effects of C3G on lipopolysaccharides (LPS)-induced inflammation on human rheumatoid fibroblast-like synoviocytes (FLS) and on collagen-induced arthritis (CIA) mice model. We treated FLS with C3G followed by LPS induction, the expressions of tumour necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β) and IL-6 and the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathway were analyzed. CIA was induced in mice and the arthritic mice were treated with C3G for 3 weeks. The disease severity was compared between control and C3G treated mice. The serum levels of TNF-α, IL-1β and IL-6 were analyzed by ELISA. C3G inhibited LPS-induced TNF-α, IL-1β and IL-6 expression in FLS. Moreover, C3G inhibited LPS-induced p65 production and IκBa, p38, ERK and JNK phosphorylation. Administration of C3G significantly attenuated disease in mice with CIA and decreased the serum l...Continue Reading

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Citations

Sep 14, 2019·Phytotherapy Research : PTR·Xu-Zhao Li, Shuai-Nan Zhang
Sep 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariusz BanachWojciech Kujawski
Apr 9, 2020·Critical Reviews in Food Science and Nutrition·Bianca R AlbuquerqueIsabel C F R Ferreira
Oct 27, 2020·Current Rheumatology Reports·Marina Bañuls-MireteMonica Guma

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