Cyanoacrylate gluing increases the effectiveness of systemic antimicrobial treatment in sternal infection: experimental study in a rodent model

The Thoracic and Cardiovascular Surgeon
M BasaranT N Ogus

Abstract

Sternal infection is a serious complication of cardiac surgery requiring resternotomy and radical debridement. In this experimental study, we aimed to test our hypothesis that the use of cyanoacrylate gluing (application of an acrylic resin, a monomer of cyanoacrylate molecules, which rapidly polymerizes in the presence of water, forming long, strong chains and joining the bonded surfaces together) together with systemic antimicrobial therapy will provide synergy for the treatment of sternal infection caused by methicillin-resistant Staphylococcus aureus (MRSA). Forty Wistar albino rats were randomly divided into four groups: Group I, uncontaminated sham group; Group II, untreated contaminated control group; Group III, contaminated group receiving only systemic vancomycin therapy; Group IV, contaminated group treated with a combination of cyanoacrylate gluing and systemic vancomycin. Cyanoacrylate gluing was applied on the 3rd postoperative day and all rats alive at the end of 8th week were sacrificed. The degree of sternal infection was assessed histologically and also by quantitative culture analysis. Histological evaluation revealed that cyanoacrylate was degraded and replaced by connective tissue at the end of the 8th week....Continue Reading

Citations

May 14, 2014·Surgical Infections·Pascal M Dohmen
Nov 1, 2014·Journal of Infection Prevention·Jeremy L RushbrookThomas Fo Taggart
Feb 20, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery

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