Cyanobacteria, neurotoxins and water resources: are there implications for human neurodegenerative disease?

Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
James S Metcalf, Geoffrey A Codd

Abstract

Cyanobacteria are cosmopolitan microbes that inhabit marine, freshwater and terrestrial environments. Under favourable conditions in waterbodies, they can form massive populations (blooms and scums), which present hazards to human and animal health. Such cyanobacteria often contain a variety of toxic substances (cyanotoxins) that can exist as both cell-associated and free forms in the surrounding water. Some cyanotoxins are highly neurotoxic and act through a variety of mechanisms. Recent findings of the production of the neurotoxin beta-N-methylamino-L-alanine (BMAA) by cyanobacteria in aquatic environments, and of BMAA in brain and cerebrospinal fluid samples of amyotrophic lateral sclerosis and Alzheimer's disease victims, raises the possibility that people may be exposed to waterborne BMAA of cyanobacterial origin and that this may contribute to human neurodegenerative disease. An understanding of the risks presented by waterborne BMAA and of available mitigation strategies to reduce this potential exposure is needed.

References

Jan 1, 1979·Toxicon : Official Journal of the International Society on Toxinology·W W CarmichaelM A Peterson
Feb 14, 1975·Science·W W CarmichaelP R Gorham
Jun 2, 1990·BMJ : British Medical Journal·P C TurnerG A Codd
Aug 1, 1994·Scientific American·D M Anderson
Mar 27, 1998·The New England Journal of Medicine·E M JochimsenW R Jarvis
Jul 10, 1999·Toxicon : Official Journal of the International Society on Toxinology·G A CoddK A Beattie
Aug 4, 2001·Environmental Health Perspectives·W W CarmichaelG K Eaglesham
Oct 12, 2001·Environmental Toxicology·S M FroscioI R Falconer
Oct 16, 2001·Toxicon : Official Journal of the International Society on Toxinology·P T OrrC L Orr
Nov 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Paul Alan CoxSusan J Murch
Jun 18, 2004·Current Opinion in Rheumatology·J S Hill Gaston
Aug 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Susan J MurchSandra Anne Banack
Mar 2, 2005·Toxicology and Applied Pharmacology·Geoffrey A CoddJames S Metcalf
Apr 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Paul Alan CoxBirgitta Bergman
Jun 13, 2006·Experimental Neurology·Shyam D RaoJohn H Weiss
Jan 15, 2008·Life Sciences·Vardan T Karamyan, Robert C Speth
Apr 15, 2008·Toxicon : Official Journal of the International Society on Toxinology·Takuya KuboKunimitsu Kaya
May 9, 2008·Marine Drugs·Sandra Anne BanackPaul Alan Cox
Jun 10, 2008·Ecotoxicology and Environmental Safety·M Esterhuizen, T G Downing
Mar 4, 2009·Acta Neurologica Scandinavica·J PabloD C Mash

❮ Previous
Next ❯

Citations

Jul 21, 2011·Analytical and Bioanalytical Chemistry·Rudolf KrskaDon Forsyth
Nov 23, 2012·PloS One·Alina A Corcoran, Wiebke J Boeing
Jan 17, 2012·Toxicon : Official Journal of the International Society on Toxinology·R C Cervantes CiancaV M Vasconcelos
Jun 11, 2015·Scientific Reports·Guangyu LiJianghua Wang
Mar 30, 2013·Toxicology Letters·Franca M BurattiEmanuela Testai
Mar 21, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Guangyu LiJianghua Wang
Jan 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yang XinHu Guoyan
Nov 26, 2019·Interdisciplinary Toxicology·Enver Ersoy AndedenBelma Aslim
Apr 16, 2021·Frontiers in Neurology·Matt KeonNitin K Saksena
Nov 8, 2017·Environmental Science & Technology·Manabu ShiraiwaKei Sato

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

© 2022 Meta ULC. All rights reserved