CYBA (p22phox) variants associate with blood pressure and oxidative stress markers in hypertension: a replication study in populations of diverse altitudes

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Rahul KumarM A Qadar Pasha

Abstract

CYBA (p22(phox)) is an integral constituent of the NADPH oxidases and is consequently a main component of oxidative stress, which is strongly associated with hypertension. This study investigates the contribution of CYBA polymorphisms toward the complex etiology of hypertension in two ethnically different populations, one located at a high altitude and the other at a low altitude. The significance of CYBA single nucleotide polymorphisms and their correlation with clinical and biochemical phenotypes were investigated in age- and ethnicity-matched unrelated permanent high-altitude residents (>3500 m) comprising 245 controls and 241 patients. The results were replicated in a second population comprising 935 controls and 545 patients who lived at a low altitude (<200 m). The analysis of covariance revealed that CYBA risk alleles and their haplotypes, rs8854A/rs9932581G/rs4873C and rs8854G/rs9932581G/rs4873C, were positively correlated with clinical parameters, for example, systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP), and biochemical parameters, for example, 8-isoPGF2α level, and inversely correlated with catalase activity in patients compared with controls (P⩽0.01, each). Conversel...Continue Reading

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Citations

Dec 15, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mohammad Z Ashraf
Jul 22, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Milica DeklevaSanja Mazic
Feb 12, 2020·Journal of Human Hypertension·Monika BuraczynskaWojciech Zaluska
Oct 26, 2018·Hypertension·Offdan Narvaez-GuerraJulio A Chirinos
Feb 7, 2019·The Pharmacogenomics Journal·Santiago CuevasPedro A Jose

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