PMID: 11914415DOI: 10.1212/wnl.58.6.956Mar 27, 2002Paper
Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam
Neurology
Paul Alan Cox, Oliver W Sacks
Abstract
The Chamorro people of Guam have been afflicted with a complex of neurodegenerative diseases (now known as ALS-PDC) with similarities to ALS, AD, and PD at a far higher rate than other populations throughout the world. Chamorro consumption of flying foxes may have generated sufficiently high cumulative doses of plant neurotoxins to result in ALS-PDC neuropathologies, since the flying foxes forage on neurotoxic cycad seeds.
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