PMID: 8947927Nov 1, 1996Paper

Cyclazocine revisited

Neurochemical Research
S ArcherJ M Bidlack

Abstract

Recently synthesized compounds which have long-term mu antagonist activity and short-term kappa agonist effects prevent self-administration of cocaine and morphine in rats. Cyclazocine, a compound synthesized in 1962 and studied in animals and man in the 1960's and in the early 1970's is a mu antagonist in rats and man and is a potent kappa agonist in both species. It also prevents self-administration of cocaine and morphine in rats. Although it produces unpleasant side effects in man, subjects become tolerant to these side effects but not to the antagonistic actions of the drug after prolonged administration.

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R SpanagelT S Shippenberg
Oct 1, 1990·Drug and Alcohol Dependence·N K MelloJ H Mendelson
Jan 1, 1989·Life Sciences·T R KostenC Morgan
Nov 1, 1971·Comprehensive Psychiatry·R B ResnickA M Freedman
Jul 1, 1966·Clinical Pharmacology and Therapeutics·W R MartinT K McClane

❮ Previous
Next ❯

Citations

Nov 10, 2013·European Journal of Pharmacology·Aashish S MoraniBronwyn M Kivell
Apr 22, 2004·Pharmacology, Biochemistry, and Behavior·Wallace B PickworthKenzie L Preston
Oct 27, 1998·European Journal of Pharmacology·S D GlickI M Maisonneuve
Mar 1, 2011·Journal of Medicinal Chemistry·Tangzhi ZhangJohn L Neumeyer
Aug 24, 2010·Acta Pharmacologica Sinica·Yu-hua WangJing-gen Liu
Sep 5, 2002·Nature Reviews. Drug Discovery·Mary Jeanne KreekEduardo Butelman
Dec 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nancy K MelloArthur J Siegel
Dec 16, 2005·The AAPS Journal·Thomas E PrisinzanoWayne W Harding
May 29, 2009·British Journal of Anaesthesia·N DietisD G Lambert
Jan 1, 2013·Cells·Cynthia Wei-Sheng Lee, Ing-Kang Ho
Mar 17, 2009·Life Sciences·Peter W Schiller
Oct 14, 2008·Pharmacology, Biochemistry, and Behavior·Nathalie V GoletianiNancy K Mello
May 20, 2015·British Journal of Pharmacology·Florence NobleNicolas Marie
Apr 9, 2008·Acta Physiologica Hungarica·S Fürst, S Hosztafi
Feb 15, 2000·Bioorganic & Medicinal Chemistry Letters·M P WentlandJ M Bidlack
Nov 26, 2008·Bioorganic & Medicinal Chemistry Letters·Mark P WentlandJean M Bidlack
Apr 20, 1999·Neuroreport·I M Maisonneuve, S D Glick
Apr 21, 2004·Behavioural Pharmacology·K L PrestonW B Pickworth
Mar 15, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carrie A BowenNancy K Mello
May 15, 2015·Organic & Biomolecular Chemistry·Surendar Reddy BathulaSrivari Chandrasekhar
Oct 1, 2013·Pharmacological Reviews·Gavril W Pasternak, Ying-Xian Pan
Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Jean M BidlackMark P Wentland
Jul 27, 2000·Annals of the New York Academy of Sciences·N K Mello, S S Negus
Jul 27, 2000·Annals of the New York Academy of Sciences·J M BidlackM P Wentland
Jul 12, 2005·CNS Drug Reviews·Juanita Dortch-Carnes, David E Potter
Dec 4, 2003·Journal of Medicinal Chemistry·Shannon L BlackStephen M Husbands
Nov 14, 2003·Journal of Medicinal Chemistry·John L NeumeyerJean M Bidlack
Feb 21, 2003·Journal of Medicinal Chemistry·Mark P WentlandJean M Bidlack

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmacology
S D GlickI M Maisonneuve
Annals of the New York Academy of Sciences
J M BidlackM P Wentland
Drug and Alcohol Dependence
P E Gilbert, W R Martin
The Journal of Pharmacology and Experimental Therapeutics
K M KumorD Jasinski
© 2021 Meta ULC. All rights reserved