Cycle abnormalities in infertile women with regular menstrual cycles: effects of clomiphene citrate treatment

Fertility and Sterility
D A RodinR N Clayton

Abstract

To investigate the incidence and nature of cycle abnormalities and the effect of clomiphene citrate (CC) treatment in women with apparently ovulatory cycles and unexplained infertility. Nonrandomized, open study of patients before and during treatment. The Reproductive Medicine Clinic of a District General Hospital. Thirty-five women with regular, apparently ovulatory menstrual cycles and unexplained infertility. Detailed ultrasound and hormonal cycle tracking was performed before and during treatment with CC. Serial ultrasound scans and measurements of serum LH, FSH, E2, and P. Before treatment, 54% of cycles were uniovulatory, 40% were characterized by cyst formation, and 6% were characterized by poor follicular growth. Fifty-one percent of pretreatment cycles had normal hormone profiles, 31% had defective luteal phases, 14% had increased early follicular phase serum FSH levels, and 9% had increased early follicular phase serum LH levels. Treatment with CC reduced the incidence of cyst formation to 9% and the incidence of luteal phase defects to 3%. However, 28% of CC-treated cycles showed ultrasound features of overstimulation and 51% had high follicular phase E2 peaks so that only 34% of CC-treated cycles had normal hormone...Continue Reading

Citations

Aug 13, 2014·Obstetrical & Gynecological Survey·Tarek A GelbayaLuciano G Nardo
Jun 16, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·P van ZonneveldE R te Velde
May 28, 2003·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S Haritha, G Rajagopalan
Nov 1, 1995·Alcohol·A Martínez-RieraE Rodríguez-Rodríguez

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