Cycle control with a 21-day compared with a 24-day oral contraceptive pill: a randomized controlled trial

Obstetrics and Gynecology
Andrew M KaunitzKatherine D LaGuardia

Abstract

To compare bleeding patterns between a 21/7-day triphasic norgestimate/ethinyl estradiol (E2) 25-microgram oral contraceptive pill (OCP) and a 24/4-day drospirenone/ethinyl E2 20-microgram OCP. In a three-cycle, open-label, multicenter study, healthy, sexually active women were assigned randomly to a 21/7-day (norgestimate/ethinyl E2) or 24/4-day (drospirenone/ethinyl E2) OCP regimen. Randomization was stratified to assure a balanced distribution between regimens for "fresh starts" and "switchers." Bleeding data were collected daily using an interactive voice-response system. Bleeding was defined according to the 2007 U.S. Food and Drug Administration's Reproductive Health Drug Advisory Committee-endorsed criteria. Across the three cycles, the 21/7-day OCP group (n=165) reported fewer unscheduled bleeding days than did the 24/4-day OCP group (n=167) (mean 4.6 compared with 6.1 days, P=.003). Women using the 21/7-day OCP had significantly fewer episodes of unscheduled bleeding than did those using the 24/4-day OCP (mean 1.47 compared with 2.01, P=.001). Moreover, women using the 21/7-day OCP had a significantly lower absence of scheduled bleeding at each cycle (P<.001). Both regimens were well-tolerated. A 21-day norgestimate/et...Continue Reading

References

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Sep 2, 2008·Obstetrics and Gynecology·Paul D Blumenthal, Alison Edelman

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Citations

Jun 15, 2011·Contraception·Ronald BurkmanDavid Serfaty
Nov 18, 2015·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Rossella E NappiJohannes Bitzer
Aug 21, 2015·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Alessandra Graziottin
Apr 18, 2017·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Amanda BlackAnne Marie Whelan
May 13, 2011·The Cochrane Database of Systematic Reviews·Theresa A LawrieA Metin Gülmezoglu
Jun 28, 2011·Menopause : the Journal of the North American Menopause Society·JoAnn V Pinkerton
Nov 12, 2010·The Journal of Family Planning and Reproductive Health Care·Anne SzarewskiLee P Shulman
Feb 12, 2019·The Cochrane Database of Systematic Reviews·Anne LethabyJulie Brown
Nov 11, 2011·The Cochrane Database of Systematic Reviews·Huib A A M Van VlietFrans M Helmerhorst
Aug 2, 2013·The Cochrane Database of Systematic Reviews·Maria F GalloKenneth F Schulz

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