PMID: 9630224Jun 18, 1998Paper

CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless

Cell
J E RutilaJ C Hall

Abstract

We report the identification, characterization, and cloning of another novel Drosophila clock gene, cycle (cyc). Homozygous cyc flies are completely arrhythmic. Heterozygous cyc/+ flies are rhythmic but have altered periods, indicating that the cyc locus has a dosage effect on period. The molecular circadian phenotype of homozygous cyc flies is like homozygous Clk flies presented in the accompanying paper: mutant flies have little or no transcription of the per and tim genes. Cloning of the gene indicates that it also encodes a bHLH-PAS transcription factor and is a Drosophila homolog of the human protein BMAL1. cyc is a nonsense mutation, consistent with its strong loss-of-function phenotype. We propose that the CYC:CLK heterodimer binds to per and tim E boxes and makes a major contribution to the circadian transcription of Drosophila clock genes.

References

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K M BurbachC A Bradfield
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P E HardinM Rosbash
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W R Pearson, D J Lipman
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R J Konopka, S Benzer
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·A C SpradlingG M Rubin
Nov 18, 1994·Science·T KondoM Ishiura
Aug 18, 1994·Nature·D Muhlrad, R Parker
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·I EderyM Rosbash
Jan 1, 1993·Journal of Biological Rhythms·D A WheelerJ C Hall
Jan 1, 1996·Annual Review of Genetics·J C Dunlap
May 16, 1997·Cell·D P KingJ S Takahashi
Jul 1, 1997·Molecular and Cellular Biology·H HaoP E Hardin
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·J B HogeneschC A Bradfield

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Citations

Jan 29, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T Kondo, M Ishiura
Jan 29, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J C Leloup, A Goldbeter
Dec 18, 2002·Journal of Neurobiology·Ralf Stanewsky
Dec 18, 2002·Journal of Neurobiology·Paul J Shaw, Paul Franken
Feb 14, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Kenji TomiokaTaishi Yoshii
Aug 30, 2008·Molecular Neurobiology·Raphaelle Dubruille, Patrick Emery
May 29, 2003·Journal of Insect Physiology·J M. Giebultowicz
Sep 1, 2000·Brain Research. Brain Research Reviews·K E van EsseveldtG J Boer
Nov 14, 2000·Trends in Genetics : TIG·A S LoudonS K Crosthwaite
Feb 26, 2000·Trends in Genetics : TIG·P L Lakin-Thomas
Jul 13, 2000·Brain Research. Molecular Brain Research·T YoshimuraS Ebihara
Oct 24, 2000·Brain Research. Molecular Brain Research·M ZhuangJ C Besharse
Mar 30, 1999·Brain Research. Molecular Brain Research·H AbeK Honma
Jul 17, 1999·Brain Research. Molecular Brain Research·P LarkinS L Semple-Rowland
Feb 11, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M E Hahn
Apr 1, 2000·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·D GonzeA Goldbeter
Nov 13, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·F W Turek, D E Kolker
May 10, 2001·Current Opinion in Cell Biology·J A Ripperger, U Schibler
Oct 31, 1998·Current Opinion in Genetics & Development·L D Wilsbacher, J S Takahashi
Nov 13, 1998·Current Opinion in Neurobiology·D WhitmoreN S Foulkes
Nov 13, 1998·Current Opinion in Neurobiology·P E Hardin
Nov 13, 1998·Current Opinion in Neurobiology·R Costa, C P Kyriacou
Sep 5, 1998·Trends in Cell Biology·C B Green
Jul 17, 1999·Trends in Cell Biology·P F Devlin, S A Kay
Mar 12, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Elitza P MarkovaMakio Takeda
Apr 4, 2000·Current Opinion in Microbiology·H Iwasaki, J C Dunlap
Mar 6, 1999·Current Opinion in Microbiology·S S GoldenT Kondo
Mar 6, 1999·Current Opinion in Microbiology·J J Loros
May 25, 2006·European Journal of Human Genetics : EJHG·Ezio RosatoCharalambos P Kyriacou
Mar 16, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yasufumi ShigeyoshiHitoshi Okamura
Apr 25, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T HosoyaY Fujii-Kuriyama
Jul 2, 1999·Journal of Sleep Research·U Schibler, M Tafti
Jun 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chihiro ItoHideharu Numata
Feb 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Adam BajgarDavid Dolezel

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