PMID: 6164765Jan 1, 1981Paper

Cyclic adenosine 3',5' monophosphate in cerebrospinal fluid of multiple sclerosis patients

Journal of Neurology
E Maida, W Kristoferitsch

Abstract

Cyclic adenosine 3',5' monophosphate (cAMP) was assayed in CSF and plasma obtained from patients with multiple sclerosis. Decreased CSF cAMP levels were found in more than half of the patients while plasma cAMP was normal. The decrease is correlated significantly with the disability of the patient and with the progression of the disease. A low CSF cAMP level can be considered as prognostically unfavorable, particularly in the early stage of the disease. There was no correlation between the cAMP levels and the duration of the disease or with bouts and remissions. ACTH therapy did not normalize the decreased values. Obviously the decrease of CSF cAMP is related to the demyelination and not to the intensity of the pathological immunoreactions.

References

Mar 22, 1979·Journal of Neurology·E Maida, K Summer
Jan 1, 1976·European Neurology·E R HeikkinenH Vapaatalo
Feb 1, 1977·Neuropharmacology·R HammersH Cramer
Jan 1, 1977·Journal of Neuroscience Research·H Cramer
Sep 27, 1979·Biochemical and Biophysical Research Communications·D RouxH L Cailla

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Citations

Oct 1, 1986·Journal of Neurology·T BüttnerW Dorndorf
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B BielekovaR Martin
Jul 17, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Abid BhatMeena Kishore Sakharkar

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