Cyclic alteration in the anticonvulsant effect of nitrous oxide in rats

Journal of Anesthesia
K ShinguK Mori

Abstract

The anticonvulsant action of nitrous oxide and its time course were studied in rats. Bicuculline, a GABA-receptor antagonist, was administered intravenously at a rate of 0.2 mg.kg(-1).min(-1) during exposure to air (n = 60) or 75% nitrous oxide in oxygen (n = 80). The convulsant dose of bicuculline was determined. The rats were divided into subgroups according to the duration of exposure to air or nitrous oxide, from 0 to 120 min at 15 min intervals. Although the convulsant dose of bicuculline was consistent in the air group (1.03 +/- 0.06 mg.kg(-1), mean +/- SEM), it showed two peaks at 30- and 90 min exposures to nitrous oxide. The threshold dose in the nitrous oxide group was significantly higher than in the air group at only 15- and 30 min exposures (1.50 +/- 0.16, 2.15 +/- 0.25 mg.kg(-1), respectively, P < 0.05). We conclude that nitrous oxide has an anticonvulsant action against bicuculline-induced seizure, and that a cyclic nature exists in its action.

References

Jan 1, 1975·International Anesthesiology Clinics·K Mori, W D Winters
Jun 1, 1979·Anesthesiology·R A SmithE I Eger
Oct 1, 1979·Anesthesiology·B A BerkowitzS H Ngai
May 1, 1976·British Journal of Anaesthesia·J G WhitwamA Petrie
Jun 1, 1970·Anesthesiology·E S MunsonR E Smith
Dec 1, 1984·Acta Anaesthesiologica Scandinavica·J RuprehtM R Dzoljic
Feb 1, 1983·British Journal of Anaesthesia·J E StevensK Mori

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Citations

Mar 7, 2020·Journal of Addiction Medicine·Sarah IckowiczSeonaid Nolan
Nov 20, 2002·Anaesthesia·K A HendersonJ E Hall

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