Jun 1, 1977

Cyclic AMP and allergic histamine release. Influence of methylxanthines on rat mast cells

Acta Allergologica
S NornR Klysner


Both isobutylmethylxanthine and theophylline increased the level of cyclic AMP in rat mast cells. Theophylline reduced the allergic histamine release, whereas isobutylmethylxanthine caused a pronounced potentiation of the histamine release. This indicates that the hypothesis of an inverse relationship between the level of cyclic AMP in mast cells and histamine release is inadequate.

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Mentioned in this Paper

Mast Cell
Cyclic AMP
Cyclic Adenosine Monophosphate Measurement
Cyclic AMP, (R)-Isomer
Theophylline Assay
Histamine Release

About this Paper

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