Jan 1, 1976

Cyclic AMP and cyclic GMP in epidermal physiology and pathophysiology

Current Problems in Dermatology
J J VoorheesE R Harrell

Abstract

The second messengers cyclic AMP and cyclic GMP in several organs appear to coordinate those molecular events which are responsible for specialized organ function. As a result of balanced cell proliferation and specialization, epidermis functions by terminal specialization which provides a barrier between man and environment. Since the epidermal component of psoriasis is a classic example of deranged epidermal homeostasis, which has a low level of cyclic AMP and a high level of cyclic GMP, it seems reasonable that rebalancing these cyclic nucleotides might ultimately be a safe and effective therapy for psoriasis and other proliferative skin diseases.

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Mentioned in this Paper

Psoriasis
Growth Inhibitors
Cyclic AMP, (R)-Isomer
Protein KINASE
Skin
Guanylate Cyclase
3',5'-Cyclic-Nucleotide Phosphodiesterase
Glycogen
M Phase, Mitotic
Cyclic GMP

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