PMID: 9194689Jan 1, 1997Paper

Cyclic AMP and cyclic GMP relax phorbol ester-induced contractions of rat aorta by different mechanisms

Life Sciences
H Y AhnR S Moreland

Abstract

This study was designed to test the hypothesis that 8-Br-cAMP and 8-Br-cGMP dependent relaxation of phorbol dibutyrate stimulated contractions of intact rat aorta are independent of changes in the level of myosin light chain phosphorylation. Phorbol dibutyrate stimulated contraction with a concomitant increase in myosin light chain phosphorylation in normal tissues and without an increase in myosin light chain phosphorylation in calcium-depleted tissues. Phorbol dibutyrate stimulated contractions in normal CaCl2-containing physiological salt solution were relaxed in a concentration-dependent manner by 8-Br-cAMP and 8-Br-cGMP. Phorbol dibutyrate-induced contractions in the absence of Ca2+ were only relaxed by 8-Br-cGMP; 8-Br-cAMP had no effect. The relaxation induced by 8-Br-cGMP was associated with a decrease in myosin light chain phosphorylation suggesting that cGMP-dependent protein kinase may alter the activity of either the myosin light chain kinase or phosphatase. The relaxation induced by 8-Br-cAMP was not associated with a decrease in phosphorylation suggesting that cAMP-dependent protein kinase may uncouple myosin light chain phosphorylation from force.

References

Sep 1, 1992·The American Journal of Physiology·R A KhalilK G Morgan
Aug 1, 1992·The American Journal of Physiology·S MorelandR S Moreland
Mar 1, 1990·The American Journal of Physiology·T M LincolnA E Taylor
Jun 1, 1990·Pflügers Archiv : European journal of physiology·H OzakiH Karaki
Sep 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A P Somlyo, B Himpens
Sep 15, 1989·Biochemical and Biophysical Research Communications·J Nishimura, C van Breemen
Jun 1, 1989·Molecular Endocrinology·C JolicoeurP A Kelly
Nov 1, 1988·European Journal of Pharmacology·H KarakiK Murakami
Oct 15, 1985·Biochemical and Biophysical Research Communications·H Umekawa, H Hidaka
Feb 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T M Lincoln, T L Cornwell
Nov 1, 1993·The American Journal of Physiology·H ItohT Nakano

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Citations

Sep 2, 1998·Progress in Neurobiology·D A Pelligrino, Q Wang
Nov 22, 2005·British Journal of Pharmacology·Ezequiel AlvarezFrancisco Orallo
Aug 2, 2007·Journal of Pharmacological Sciences·Takeharu KanedaKazumasa Shimizu

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