Cyclic AMP and neuroendocrine influence upon forelimb regeneration in the adult newt, Notophthalmus viridescens

Oncology
R E Sicard

Abstract

The influence of the nervous and endocrine systems upon successive stages of limb regeneration suggest possible neuroendocrine interaction(s). Intraperitoneal injections of various agents had no effects upon blastema formation. Chlorpromazine, administered alone or with hormones, retarded morphogenesis. Prolactin, dibutyryl cAMP (db-cAMP), theophylline, and acetylcholine accelerated morphogenesis. 5'-AMP had no effect. Only db-cAMP countered the chlorpromazine-induced retardation of morphogenesis. These results suggest that neuroendocrine influences, possibly cAMP-mediated, direct, in part, the morphogenesis of the regeneration blastema.

Citations

Aug 1, 1986·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·A KesikM Globus
Feb 1, 1983·The Journal of Experimental Zoology·H M McLaughlinD S McLaughlin
May 1, 1982·Wilhelm Roux's Archives of Developmental Biology·Thomas M Laz, Raymond E Sicard
Jun 1, 1980·Wilhelm Roux's Archives of Developmental Biology·Janet M Carroll, Raymond E Sicard

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