PMID: 1797Dec 1, 1975

Cyclic-AMP and pancreatic bicarbonate secretion in response to secretin in dogs

Proceedings of the Society for Experimental Biology and Medicine
S DomschkeL Demling


In anesthetized dogs given secretin intravenously in doses doubling every 60 min and ranging from 0.5 to 8 units per kg body weight per hr, cyclic-AMP levels in pancreatic tissue rose continuously, whereas DNA concentrations were slightly decreased. Bicarbonate concentrations and bicarbonate outputs, cyclic-AMP tissue concentrations and bicarbonate outputs, as well as cyclic-AMP tissue concentrations and juice outputs, were significantly correlated. In conscious pancreatic fistula dogs, there was also a significant correlation between cyclic-AMP and bicarbonate concentrations and outputs in the pancreatic juice after stimulation by exogenous secretin. Accordingly, enhanced release of endogenous secretin achieved by intraduodenal acidification led to a dose-dependent increase in bicarbonate and cyclic-AMP outputs in both conscious and anesthetized dogs. Phosphodiesterase inhibitors (aminophylline, caffeine, and papaverine) given alone to the conscious dogs did not initiate pancreatic bicarbonate secretion, but they potentiated bicarbonate responses to exogenous secretin. These data suggest that cyclic-AMP plays a part in secretin-stimulated pancreatic secretion.


Mar 1, 1984·Pflügers Archiv : European journal of physiology·H J BeijerG A Charbon
Jan 1, 1978·Irish Journal of Medical Science·S J Konturek
Jun 11, 1993·European Journal of Pharmacology·A HoriuchiS Chiba
May 13, 1976·The New England Journal of Medicine·P L RayfordJ C Thompson
Jan 1, 1982·The Journal of Surgical Research·O HolianC T Bombeck
Jul 31, 1980·Biochemical and Biophysical Research Communications·O HolianL M Nyhus
May 1, 1978·Biological Reviews of the Cambridge Philosophical Society·R M Case

Related Concepts

Cyclic AMP, (R)-Isomer
Carbonic Acid Ions
DNA, Double-Stranded
Canis familiaris
Hydrogen-Ion Concentration
Pancreatic Juice

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