Oct 9, 1989

Cyclic AMP calcium and the growth of mastocytoma cells

Biochimica Et Biophysica Acta
T LintsR K Ralph

Abstract

Arresting P815 mastocytoma cell growth with N6, O2'-dibutyryladenosine 3':5' cyclic monophosphate (db cAMP) and theophylline increased 45Ca2+ uptake and efflux by the cells (i.e, Ca2+ cycling) without altering cytoplasmic free Ca2+ concentrations or the amount or distribution of protein kinase C in the cells. Attempts to identify the Ca2+ channels involved using a wide variety of drugs were unsuccessful. However, the inhibitory effect of db cAMP on growth was greatly increase in medium containing low Ca2+ concentrations, confirming that interactions between Ca2+ and cyclic AMP can affect mastocytoma cell growth.

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Mentioned in this Paper

Calcium Radioisotopes
Calcium [EPC]
Ca(2+)-Transporting ATPase
Calcium
Protoplasm
Uptake
Carbonyl Cyanide m-Chlorophenyl Hydrazone
Cyclic AMP
Calcium Channel
Mast Cell Neoplasm

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