Cyclic AMP-dependent phosphorylation in the control of biotransformation in the liver

Biochemical Pharmacology
G BánhegyiJ Mandl

Abstract

The possibility of a short-term cAMP-dependent regulation of mixed-function oxidation and of glucuronide formation was investigated in isolated mouse hepatocytes and in mouse liver microsomal membranes. N6, O2-dibutyryl cAMP (in accordance with its increasing effect on gluconeogenesis) decreased aminopyrine oxidation and p-nitrophenol conjugation in isolated hepatocytes, while the phenolphthalein conjugation remained unaltered. Similar to dibutyryl cAMP the Ca2+ ionophore A 23187 also decreased aminopyrine oxidation. In cell-free systems the phosphorylation of isolated microsomal membranes by the exogenous cAMP-dependent protein kinase was inhibitory on aminopyrine oxidation and p-nitrophenol glucuronide formation but aniline oxidation and phenolphthalein glucuronidation were not affected. The correlation between the negative cAMP-dependent control of certain processes of biotransformation and the positive cAMP-dependent regulation of gluconeogenesis is discussed.

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Citations

Jun 1, 1992·The International Journal of Biochemistry·G GalántaiG Bánhegyi
Jan 1, 1991·Reproductive Toxicology·Q P LeeM R Juchau
Jul 1, 1992·Archives of Gerontology and Geriatrics·V V Frolkis, G I Paramonova
Nov 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L BraunG Bánhegyi

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