Cyclic AMP-dependent phosphorylation in the control of biotransformation in the liver

Biochemical Pharmacology
G BánhegyiJ Mandl


The possibility of a short-term cAMP-dependent regulation of mixed-function oxidation and of glucuronide formation was investigated in isolated mouse hepatocytes and in mouse liver microsomal membranes. N6, O2-dibutyryl cAMP (in accordance with its increasing effect on gluconeogenesis) decreased aminopyrine oxidation and p-nitrophenol conjugation in isolated hepatocytes, while the phenolphthalein conjugation remained unaltered. Similar to dibutyryl cAMP the Ca2+ ionophore A 23187 also decreased aminopyrine oxidation. In cell-free systems the phosphorylation of isolated microsomal membranes by the exogenous cAMP-dependent protein kinase was inhibitory on aminopyrine oxidation and p-nitrophenol glucuronide formation but aniline oxidation and phenolphthalein glucuronidation were not affected. The correlation between the negative cAMP-dependent control of certain processes of biotransformation and the positive cAMP-dependent regulation of gluconeogenesis is discussed.


Jan 1, 1978·Methods in Enzymology·C S LieberR Teschke
Sep 16, 1985·European Journal of Biochemistry·P Cohen
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S C KhaniM J Coon
Mar 20, 1974·Biochimica Et Biophysica Acta·S J PilkisC R Park
Jan 1, 1974·Reviews of Physiology, Biochemistry and Pharmacology·K Decker, D Keppler
Oct 1, 1969·European Journal of Biochemistry·R G Thurman, R Scholz
Nov 4, 1969·Biochimica Et Biophysica Acta·A Winsnes
Feb 4, 1982·Biochimica Et Biophysica Acta·T RomhányiA Faragó
Jul 31, 1984·Biochemical and Biophysical Research Communications·W PyerinC R Wolf
Mar 1, 1984·Archives of Biochemistry and Biophysics·K W Miller, C S Yang

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Jun 1, 1992·The International Journal of Biochemistry·G GalántaiG Bánhegyi
Jan 1, 1991·Reproductive Toxicology·Q P LeeM R Juchau
Jul 1, 1992·Archives of Gerontology and Geriatrics·V V Frolkis, G I Paramonova
Nov 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L BraunG Bánhegyi

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