Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels.

Frontiers in Physiology
Jennifer van der HorstThomas A Jepps

Abstract

Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can activate numerous downstream effector proteins, generating downstream signaling pathways that regulate many functions in cells. A role for cAMP in ion channel regulation has been established, and recent findings show that cAMP signaling plays a role in Kv7 channel regulation. Although cAMP signaling is recognized to regulate Kv7 channels, the precise molecular mechanism behind the cAMP-dependent regulation of Kv7 channels is complex. This review will summarize recent research findings that support the mechanisms of cAMP-dependent regulation of Kv7 channels.

References

Jan 1, 1979·Annual Review of Biochemistry·E G Krebs, J A Beavo
Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·T Braun, R F Dods
Dec 1, 1991·The American Journal of Physiology·K B Walsh, R S Kass
Sep 1, 1987·Pflügers Archiv : European journal of physiology·P B Bennett, T B Begenisich
Feb 1, 1989·Trends in Biochemical Sciences·J E DumontP P Roger
Oct 15, 1984·Experientia·W J Malaisse, F Malaisse-Lagae
Jan 6, 1995·The Journal of Biological Chemistry·R Taussig, A G Gilman
Jan 1, 1995·Annual Review of Cell and Developmental Biology·P Sassone-Corsi
Jul 1, 1996·British Journal of Pharmacology·M DienerE Scharrer
Jan 1, 1997·Annual Review of Physiology·N V Marrion
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·L B LesterJ D Scott
Feb 7, 1998·Science·C BiervertO K Steinlein
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·H CruzblancaB Hille
Dec 18, 1998·Science·H KawasakiA M Graybiel
Apr 2, 1999·Trends in Pharmacological Sciences·W F Simonds
Jan 26, 2000·Nature·B C SchroederT J Jentsch
Mar 10, 2000·Quarterly Reviews of Biophysics·G W Abbott, S A Goldstein
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·T KharkovetsT J Jentsch
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·E C CooperL Y Jan

❮ Previous
Next ❯

Citations

Feb 4, 2021·The Journal of General Physiology·Jennifer van der HorstThomas A Jepps
Sep 23, 2021·American Journal of Physiology. Cell Physiology·Harpreet Singh

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPases
co-immunoprecipitation

Related Concepts

Related Feeds

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

Related Papers

Frontiers in Physiology
Gema Mondéjar-ParreñoAngel Cogolludo
Frontiers in Cardiovascular Medicine
Andreas L Fosmo, Øyvind B Skraastad
Current Topics in Medicinal Chemistry
W Dalby-BrownSøren-P Olesen
Pflügers Archiv : European journal of physiology
Snezana MaljevicHolger Lerche
Oncotarget
Ivan Rivera-ArconadaJose Antonio Lopez-Garcia
© 2021 Meta ULC. All rights reserved