Abstract
Properties of the norepinephrine (NE) stimulated, cAMP-generating system were studied in rat hippocampal slices. NE but not other putative neurotransmitters, caused a 3--4-fold rise in cAMP levels in the slices. All 3 main subdivisions of the hippocampus (HPC), the dentate gyrus, areas CA3 and CA1, possessed the capacity to produce cAMP. The latency to the NE stimulation of cAMP formation was about 20 sec but maximal stimulation was reached only after 5--10 min of incubation. Intrahippocampal injection of kainic acid (KA) caused a nearly complete destruction of hippocampal neurons and a marked increase in number of glial cells. NE caused a 12--15-fold rise in cAMP levels in KA-treated HPC. Compared to normal HPC where potency order of noradrenergic agonists indicated activation of a beta-1 receptor type, the pattern for the KA-treated HPC indicated the dominance of beta-2 receptors. The beta-1 antagonist, practolol, and the beta-2 antagonist, H35/25, were about equipotent in blocking the NE-stimulated cAMP formation in normal HPC. In KA-treated HPC, on the other hand, H35/25 was much more potent than practolol in inhibiting NE-stimulated cAMP formation. It is suggested that in the HPC beta-1 adrenergic receptors are primarily n...Continue Reading
References
Jun 1, 1976·European Journal of Pharmacology·J B BlumbergF Sulser
Sep 16, 1976·Nature·J T Coyle, R Schwarcz
Aug 11, 1978·Brain Research·K P MinnemanP C Emson
Apr 20, 1979·Science·T J HerbstJ A Ferrendelli
May 25, 1979·Science·K P MinnemanP B Molinoff
Apr 1, 1979·Agents and Actions·J M PalaciosJ C Shwartz
May 1, 1976·European Journal of Pharmacology·A S Horn, O T Phillipson
May 1, 1977·Journal of Neurochemistry·D Wilkening, M H Makman
Jul 18, 1975·Brain Research·S R NahorskiC Edwards
Jul 1, 1977·Journal of Neurochemistry·L L Iversen
Feb 1, 1971·The Biochemical Journal·B L BrownA M Sgherzi
Dec 30, 1971·Annals of the New York Academy of Sciences·G A Robison, E W Sutherland
Aug 4, 1972·Science·F E BloomH J Wedner
May 31, 1974·Brain Research·M Segal, F E Bloom
Dec 20, 1974·Science·J FornP Greengard
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Gilman, M Nirenberg
Feb 23, 1972·Nature: New Biology·R A Burges, K J Blackburn
Feb 1, 1969·European Journal of Pharmacology·B Levy, B E Wilkenfeld
May 19, 1980·Brain Research·R S ChangS H Snyder
Jan 20, 1980·Brain Research·K A Crutcher, J N Davis
Apr 28, 1980·Brain Research·R N PittmanP B Molinoff
Feb 9, 1981·Brain Research·M Segal
Citations
May 23, 1983·Brain Research·I KarnushinaJ W Daly
Feb 13, 1984·Brain Research·G G Leblanc, R D Ciaranello
Mar 6, 1992·Brain Research·L E Chavez-Noriega, C F Stevens
Aug 9, 1988·European Journal of Pharmacology·J C Fowler, J M O'Donnell
Aug 1, 1982·Pharmacology, Biochemistry, and Behavior·R JorkH Matthies
Oct 1, 1989·Brain Research. Brain Research Reviews·E A Stone, M A Ariano
Mar 1, 1989·Brain Research. Molecular Brain Research·N Petitti, A M Etgen
Jan 1, 1987·Progress in Neuro-psychopharmacology & Biological Psychiatry·C W Harley
Jan 1, 1983·Progress in Neurobiology·G C Palmer
Oct 8, 1986·Neuroscience Letters·J E Warnick, T C Pellmar
May 1, 1990·Brain Research Bulletin·R E Brinton
Mar 12, 2004·Progress in Neurobiology·P V Nguyen, N H Woo
Sep 28, 1999·Peptides·F HernándezA M Martinez
Jan 7, 2000·Neuroscience·A Bouron, H Reuter
Feb 1, 1994·The European Journal of Neuroscience·J S RudgeE M Pasnikowski
Jul 1, 1990·Journal of Neurochemistry·M N Gannon, B S McEwen
Dec 1, 1993·Journal of Neurochemistry·A el TamerI Hanin
Sep 5, 1983·Brain Research·G L ForloniH Ladinsky
Dec 9, 1985·Brain Research·P K Stanton, J M Sarvey
Oct 9, 1989·Brain Research·F M SesslerB D Waterhouse
Aug 1, 1982·Journal of Neurochemistry·R Hofstein, M Segal
Oct 1, 1983·Journal of Neurochemistry·A PoliO Barnabei
Jan 1, 1987·CRC Critical Reviews in Biochemistry·Y Dudai
Mar 6, 1983·Nature·H L Haas, A Konnerth