Cyclic AMP-induced repair of zebrafish spinal circuits

Science
Dimple H BhattJoseph R Fetcho

Abstract

Neurons in the human central nervous system (CNS) are unable to regenerate, as a result of both an inhibitory environment and their inherent inability to regrow. In contrast, the CNS environment in fish is permissive for growth, yet some neurons still cannot regenerate. Fish thus offer an opportunity to study molecules that might surmount the intrinsic limitations they share with mammals, without the complication of an inhibitory environment. We show by in vivo imaging in zebrafish that post-injury application of cyclic adenosine monophosphate can transform severed CNS neurons into ones that regenerate and restore function, thus overcoming intrinsic limitations to regeneration in a vertebrate.

References

Jan 27, 1997·The Journal of Comparative Neurology·T BeckerM Schachner
Jun 29, 2000·Annual Review of Biochemistry·A J Shaywitz, M E Greenberg
Apr 13, 2001·Neuron·K HaasH T Cline
Feb 9, 2002·Science·Martin E Schwab
Apr 27, 2002·Nature Neuroscience·Hung-Teh KaoPaul Greengard
May 31, 2002·Nature·Tadzia GrandPréStephen M Strittmatter
Jun 28, 2002·Neuron·Jin QiuMarie T Filbin
Jul 19, 2002·Neuron·William D SniderAnnette Markus
Mar 12, 2003·The Journal of Comparative Neurology·Oswald StewardMarc Tessier-Lavigne
Apr 30, 2003·Neuron·Binhai ZhengMarc Tessier-Lavigne
Aug 29, 2003·Nature·Helen Pearson

❮ Previous
Next ❯

Citations

Aug 3, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Stefan Klussmann, Ana Martin-Villalba
Dec 17, 2004·Nature·Mehmet Fatih YanikAdela Ben-Yakar
Jul 20, 2010·Nature Methods·Carlos Pardo-MartinMehmet Fatih Yanik
Jan 24, 2012·Nature Methods·Matthew J FarrarChris B Schaffer
Nov 11, 2008·Nature Neuroscience·David L McLeanJoseph R Fetcho
Apr 5, 2007·Nature Protocols·Jennifer E BestmanHollis T Cline
Feb 3, 2005·Nature Reviews. Drug Discovery·Leonard I Zon, Randall T Peterson
Oct 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chrysanthi SamaraMehmet Fatih Yanik
Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Anna Letizia Allegra MascaroFrancesco S Pavone
Jul 22, 2010·Cold Spring Harbor Protocols·Kenric J Hoegler, John H Horne
Mar 8, 2007·Annual Review of Neuroscience·Zu-Lin ChenSidney Strickland
Oct 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David L McLean, Joseph R Fetcho
Mar 17, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Allison F RosenbergMichael Granato
Mar 6, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anindya Ghosh-RoyAndrew D Chisholm
Aug 24, 2011·Journal of Visualized Experiments : JoVE·Kenric J HoeglerJohn H Horne
Sep 13, 2007·Proceedings of the National Academy of Sciences of the United States of America·Zilu WuAndrew D Chisholm
Apr 12, 2014·Experimental Neurology·Lisa K Briona, Richard I Dorsky
Jul 16, 2011·Annual Review of Biomedical Engineering·Mehmet Fatih YanikCarlos Pardo-Martin
Jul 16, 2014·PeerJ·Stéfan van der WaltUNKNOWN scikit-image contributors
Sep 20, 2005·Molecular and Cellular Neurosciences·J RodgerA R Harvey
Sep 15, 2012·Annual Review of Genetics·Rachid El Bejjani, Marc Hammarlund
Dec 20, 2007·The American Journal of the Medical Sciences·Robert I HenkinA Papathanassiu
Sep 13, 2011·Trends in Cell Biology·Lizhen Chen, Andrew D Chisholm
Nov 10, 2010·Brain Research Reviews·Ruxandra F Sîrbulescu, Günther K H Zupanc
Mar 5, 2016·Experimental Neurology·Jeffrey P Rasmussen, Alvaro Sagasti
Jan 6, 2009·Toxicology and Applied Pharmacology·Latoya T ThomasKurt R Svoboda
Dec 2, 2008·Molecular and Cellular Neurosciences·Christian Brösamle, Marnie E Halpern
Aug 28, 2007·Experimental Neurology·Sari S Hannila, Marie T Filbin
Sep 11, 2007·Brain Research Reviews·Joseph R FetchoDavid L McLean
Jan 20, 2007·Progress in Neurobiology·Ferdinando RossiLuigi Corvetti
Jul 28, 2009·Developmental Neurobiology·Thomas PietriPhilip Washbourne
Dec 5, 2008·Journal of Neurochemistry·Massimo A Hilliard
Oct 7, 2006·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Joseph R Fetcho
Nov 14, 2008·The Journal of Comparative Neurology·Evdokia Menelaou, Kurt R Svoboda
Oct 31, 2012·The European Journal of Neuroscience·Hong-Chao PanMelitta Schachner
Feb 10, 2011·Genesis : the Journal of Genetics and Development·Sandra RiegerAlvaro Sagasti
Jul 28, 2009·Metabolism: Clinical and Experimental·Robert Irwin Henkin, I Velicu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved