Cyclic AMP is a hepatorenal link influencing natriuresis and contributing to glucagon-induced hyperfiltration in rats

The Journal of Clinical Investigation
M AhloulayL Bankir

Abstract

The effects of glucagon (G) on proximal tubule reabsorption (PTR) and GFR seem to depend on a prior action of this hormone on the liver resulting in the liberation of a mediator and/or of a compound derived from amino acid metabolism. This study investigates in anesthetized rats the possible contribution of cAMP and urea, alone and in combination with a low dose of G, on phosphate excretion (known to depend mostly on PTR) and GFR. After a 60-min control period, cAMP (5 nmol/min x 100 grams of body weight [BW]) or urea (2.5 micromol/min x 100 grams BW) was infused intravenously for 200 min with or without G (1.2 ng/min x 100 grams BW, a physiological dose which, alone, does not influence PTR or GFR). cAMP increased markedly the excretion of phosphate and sodium (+303 and +221%, respectively, P < 0.01 for each) but did not alter GFR. Coinfusion of cAMP and G induced the same tubular effects but also induced a 20% rise in GFR (P < 0.05). Infusion of urea, with or without G, did not induce significant effects on PTR or GFR. After G infusion at increasing doses, the increase in fractional excretion of phosphate was correlated with a simultaneous rise in plasma cAMP concentration and reached a maximum for doubling of plasma cAMP. The...Continue Reading

References

Jan 14, 1975·Biochimica Et Biophysica Acta·R A Podevin, E F Boumendil-Podevin
Jun 19, 1975·The New England Journal of Medicine·R F SparkJ T O'Brian
Apr 1, 1975·European Journal of Clinical Investigation·R C Strange, O D Mjos
Oct 1, 1976·Metabolism: Clinical and Experimental·T V Zenser, B B Davis
Jun 1, 1977·European Journal of Clinical Investigation·G N HendyJ L O'Riordan
Apr 1, 1979·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J UrangaE del Castillo
Nov 1, 1991·Pflügers Archiv : European journal of physiology·C de RouffignacN Roinel
Jan 1, 1990·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G FriedlanderC Amiel
Sep 1, 1989·Pflügers Archiv : European journal of physiology·A Di StefanoC de Rouffignac
Aug 1, 1985·Pflügers Archiv : European journal of physiology·D Butlen, F Morel
Jan 1, 1988·Kidney International·A Claris-AppianiG Cavanna
Apr 1, 1986·Kidney International·J M ElaloufC de Rouffignac
Dec 30, 1971·Annals of the New York Academy of Sciences·J H ExtonC R Park
Jan 1, 1974·The Journal of Clinical Investigation·J E LiljenquistG W Liddle
Aug 1, 1972·Kidney International·M Levy, N L Starr
Jun 1, 1974·The Journal of Clinical Endocrinology and Metabolism·J T O'BrianR A Arky
Jun 10, 1968·Biochemical and Biophysical Research Communications·M W BitenskyW Robertson
Apr 1, 1967·Metabolism: Clinical and Experimental·T N PullmanI Aho
Nov 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·O SøvikS Selvig
Apr 1, 1983·European Journal of Clinical Investigation·J J Holst
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C BaillyF Morel
Feb 1, 1982·Pflügers Archiv : European journal of physiology·C Bailly, C Amiel
Jun 1, 1995·Kidney International·G Friedlander, C Amiel
Dec 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·K HoogenbergW J Sluiter

❮ Previous
Next ❯

Citations

Sep 2, 2008·Annual Review of Physiology·Jang H Youn, Alicia A McDonough
Aug 28, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Brian J MorrisRuby C Y Lin
Nov 18, 2014·The Journal of Clinical Investigation·Yassine SassiStefan Engelhardt
Feb 9, 2011·Journal of Immunotoxicology·Helen V Ratajczak
Nov 18, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Aleksander KragFlemming Bendtsen
Mar 23, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Mina AhloulayDidier Lebrec
Jun 12, 2013·Journal of the American College of Cardiology·Frederik H VerbruggeWilfried Mullens
May 19, 2017·The Journal of Endocrinology·Sihan LvBing Luan
May 20, 2016·American Journal of Physiology. Renal Physiology·Lise BankirGilles Crambert
Jul 23, 2003·Journal of Human Hypertension·A BarbatoF P Cappuccio
Jul 24, 2008·American Journal of Physiology. Endocrinology and Metabolism·Pritpal Bansal, Qinghua Wang
Aug 16, 2018·The Journal of Pharmacology and Experimental Therapeutics·Gabriela Maria BertollottoFabiola Zakia Mónica
Mar 29, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B PouzetL Bankir
Feb 8, 2002·American Journal of Physiology. Renal Physiology·Lise BankirCarole A Parent
Oct 4, 2000·Physiological Reviews·H MurerJ Biber
Dec 12, 2001·American Journal of Physiology. Renal Physiology·Katherine R TuttleRobert A Short
Oct 12, 2007·Physiology·Aldebaran M Hofer, Konstantinos Lefkimmiatis
Jan 14, 1999·The American Journal of Physiology·A Claris-AppianiB M Assael
Nov 4, 2004·Experimental Biology and Medicine·Gale B CareyKristen C Overman
May 1, 2015·American Journal of Physiology. Renal Physiology·Lise BankirNadine Bouby
Aug 26, 1998·Metabolism: Clinical and Experimental·T YamamotoK Higashino

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Shigeaki MutoEiji Kusano
© 2021 Meta ULC. All rights reserved