Cyclic AMP level of human thyroid cells in monolayer culture. TSH induced refractoriness to TSH action

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
Y Kaneko


Thyroid cells from euthyroid patients with Graves' disease were cultured in a chemically defined medium. The cells preserved the ability to respond to TSH with 8-fold increase in cyclic AMP concentration. This cyclic AMP response to TSH was diminished by prior exposure of cells to TSH. The decrease in cyclic AMP response to TSH induced to TSH was reversible, was not associated with a similar decrease to cyclic AMP response to PGE1, and could not be attributed to increased phosphodiesterase activity or to decreased adenyl cyclase activity. The partial resistence to TSH stimulation of thyroid cells previously exposed to TSH may be due to changes in the TSH receptor, possibly caused by TSH itself.


Aug 2, 1979·The New England Journal of Medicine·A J Van HerleJ E Dumont
Apr 1, 1990·Metabolism: Clinical and Experimental·M Taguchi, J B Field
Dec 1, 1984·Journal of Endocrinological Investigation·L E Ericson, V Johanson
Jan 1, 1980·Endocrine Research Communications·S D Holmes, J B Field

Related Concepts

Adherent Culture
Cyclic AMP
Thyroid Diseases
Cyclic Adenosine Monophosphate Measurement
Biologic Preservation
Cyclic AMP, (R)-Isomer
Thyroid (USP)

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