PMID: 9523569Apr 2, 1998Paper

Cyclic AMP resets the circadian clock in cultured Xenopus retinal photoreceptor layers

Journal of Neurochemistry
Minoru Hasegawa, Gregory M Cahill

Abstract

The Xenopus retinal photoreceptor layer contains a circadian oscillator that regulates melatonin synthesis in vitro. The phase of this oscillator can be reset by light or dopamine. The phase-response curves for light and dopamine are similar, with transitions from phase delays to phase advances in the mid-subjective night. Light and dopamine each can inhibit adenylate cyclase in retinal photoreceptors, suggesting cyclic AMP as a candidate second messenger for entrainment of the circadian oscillator. We report here that treatments that increase intracellular cyclic AMP reset the phase of the photoreceptor circadian oscillator, and that the phase-response curves for these treatments are 180 degrees out of phase with the phase-response curves for light and dopamine. Activation of adenylate cyclase by forskolin during the late subjective day or early subjective night caused phase advances. The same treatment during the late subjective night or early subjective day caused phase delays. Similar phase shifts were induced by 3-isobutyl-1-methylxanthine (a phosphodiesterase inhibitor) or 8-(4-chlorophenylthio)cyclic AMP. All of these treatments also acutely increased melatonin release. Forskolin and 3-isobutyl-1-methylxanthine increased...Continue Reading

Citations

Jun 18, 1999·Chronobiology International·E D Herzog, G D Block
Aug 15, 2000·Microscopy Research and Technique·F E Anderson, C B Green
Mar 25, 2004·Journal of Biological Rhythms·Carla B Green, Joseph C Besharse
May 25, 2004·Journal of Biological Rhythms·Minoru Hasegawa, Gregory M Cahill
Apr 21, 2016·Journal of Biological Rhythms·Joseph C Besharse, Douglas G McMahon
Oct 3, 2018·The European Journal of Neuroscience·Gladys Y-P Ko
Jun 25, 2009·Journal of Neurochemistry·Gladys Y-P KoMichael L Ko
Apr 23, 2005·Progress in Retinal and Eye Research·P Michael IuvoneShyam S Chaurasia

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