Cyclic AMP response element modulator-1 (CREM-1) involves in neuronal apoptosis after traumatic brain injury.

Journal of Molecular Neuroscience : MN
Xinmin WuYilu Gao

Abstract

The cyclic AMP response element-binding protein (CREB) family can regulate biological functions of various types of cells by forming homo- or heterodimers to bind the target DNA sequences; it plays an essential role in individual neuronal function and entire neuronal circuits. One attractive activity of the CREB family is regulating the transcription of apoptosis-suppressor gene bcl-2. Cyclic AMP response element modulator-1 (CREM-1) is one member of the family with limited acquaintance. To investigate whether CREM-1 is involved in central nervous system injury and repair, we performed an acute traumatic brain injury (TBI) model in adult rats. Western blot analysis and immunohistochemistry showed a significant upregulation of CREM-1 in ipsilateral peritrauma cortex. Immunofluorescent labeling indicated that CREM-1 was localized mainly in the nuclei of neurons; co-localization of CREM-1 and active-caspase-3 in the ipsilateral cortex suggested that CREM-1 might participate in neuronal apoptosis. To further investigate the function of CREM-1, a neuronal cell line PC12 was employed to establish an apoptosis model. We analyzed the association of CREM-1 with p-CREB on PC12 cells by Western blot, immunofluorescent labeling, and co-imm...Continue Reading

References

Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·J M JürgensmeierJ C Reed
Jan 26, 2000·Journal of Neurochemistry·R S ClarkS H Graham
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·B Mayr, M Montminy
Dec 18, 2001·Journal of Neuroscience Research·S G KernieL F Parada
Feb 8, 2002·Molecular Neurobiology·A G Yakovlev, A I Faden
Apr 24, 2002·Experimental Cell Research·Giuseppe ServilloPaolo Sassone-Corsi
Jan 31, 2003·Acta Neuropathologica·André WennerstenTiit Mathiesen
Jun 14, 2003·Journal of Neurotrauma·Ramesh RaghupathiTracy K McIntosh
Feb 3, 2004·The Journal of Biological Chemistry·Dominique Sawka-VerhelleChristopher K Glass
Sep 22, 2005·Neurocritical Care·Jill WongIvan Ng
Nov 3, 2005·Journal of Cell Science·Florent AllagnatJacques-Antoine Haefliger
Jul 19, 2008·Lancet Neurology·Andrew I R MaasRoss Bullock
Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Bogdan A Stoica, Alan I Faden
May 28, 2010·Journal of Neurotrauma·Nicole Zangrilli HohYvette P Conley
Nov 3, 2010·Trends in Pharmacological Sciences·David J Loane, Alan I Faden
Jan 7, 2011·Molecular and Cellular Biochemistry·Mohammad Shamsul OlaHaseeb Ahsan
Mar 3, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tobias EngelDavid C Henshall
Jul 19, 2011·Developmental Cell·Jean-Claude Martinou, Richard J Youle
Sep 29, 2011·Molecular Neurobiology·Angel Barco, Hélène Marie
Nov 8, 2011·Lancet Neurology·Jed A HartingsUNKNOWN Co-Operative Study on Brain Injury Depolarisations

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Citations

Apr 19, 2013·Journal of Molecular Histology·Debao LiZhiming Cui
Nov 28, 2012·Journal of Molecular Neuroscience : MN·Jinlong ZhangZhiming Cui
Feb 7, 2013·Journal of Molecular Neuroscience : MN·Kaifu KeMaohong Cao
Aug 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuchan WangJianguo Zhang
Jun 24, 2014·PloS One·Jun ChenAnn M Marini
Oct 30, 2013·Journal of Molecular Neuroscience : MN·Yue XuXiaoling Liang
Mar 18, 2016·Journal of Molecular Histology·Wei JinChuancheng Ren
Apr 22, 2015·Inflammation·Xinhui ZhuDongmei Zhang
Nov 20, 2014·Cellular and Molecular Neurobiology·Ming DaiAimin Sang
Nov 6, 2014·Cellular and Molecular Neurobiology·Kaifu KeMaohong Cao

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