PMID: 15226456Jul 1, 2004Paper

Cyclic AMP stimulates fructose transport in neonatal rat small intestine

The Journal of Nutrition
Xue-Lin CuiRonaldo P Ferraris

Abstract

Intestinal fructose transporter (GLUT5) expression normally increases significantly after completion of weaning in neonatal rats. Increases in GLUT5 mRNA, protein, and activity can be induced in early weaning pups by precocious consumption of dietary fructose or by perfusion of the small intestine with fructose solutions. Little is known about the signal transduction pathway of the dietary fructose-mediated increase in GLUT5 expression during early intestinal development. Recent microarray results indicate that key gluconeogenic enzymes modulated by cAMP are markedly upregulated by fructose perfusion; hence, we tested the hypothesis that cAMP plays an important role in regulating intestinal fructose absorption by simultaneously perfusing adenylyl cyclase, phosphodiesterase, or protein kinase A (PKA) inhibitors along with fructose. Intestinal fructose uptake rates increased by 100% in rat pups perfused with 8-bromo-cAMP. Simultaneous fructose and dideoxyadenosine (DDA; inhibitor of adenylyl cyclase) perfusion completely inhibited increases in fructose uptake rate induced by perfusion with fructose alone. Fructose perfusion increased intestinal mucosal cAMP concentrations by 27%, but simultaneous perfusion of fructose and DDA inh...Continue Reading

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Citations

Apr 6, 2006·World Journal of Gastroenterology : WJG·Laurie A Drozdowski, Alan B R Thomson
Mar 29, 2019·Chronobiology International·Shumin SunHiroaki Oda
Jan 8, 2020·Nutrients·Beatriz MerinoGerman Perdomo
Apr 11, 2008·The American Journal of Clinical Nutrition·Séverine KirchnerRonaldo P Ferraris
Feb 5, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xue-Lin CuiRonaldo P Ferraris
Jul 16, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yasuhiro KimuraRandal K Buddington
Apr 10, 2008·American Journal of Physiology. Endocrinology and Metabolism·Veronique Douard, Ronaldo P Ferraris
Sep 8, 2010·Journal of Clinical Gastroenterology·Moe Htet Kyaw, John Francis Mayberry
Nov 11, 2008·The Journal of Nutritional Biochemistry·Laurie A DrozdowskiAlan B R Thomson

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