Cyclic and age-related changes in norepinephrine concentrations in the medial preoptic area and arcuate nucleus

Brain Research Bulletin
P S MohanKumarS K Quadri

Abstract

High-performance liquid chromatography with electrochemical detection (HPLC-EC) and Palkovits' microdissection technique were used to measure norepinephrine (NE) concentrations in the medial preoptic area (MPA) and arcuate nucleus (AN) during various stages of the estrous cycle. NE was measured seven times at 2-h intervals between 1000 h and 2200 h on the days of proestrus and diestrus in young (4-month-old) rats and four times at 2-h intervals between 1400 h and 2000 h in old (20-22-month-old) persistently diestrous rats. On the day of proestrus in young animals, NE increased progressively from low levels at 1000 h to peak levels at 2000 h, followed by a sharp decline at 2200 h. In contrast, no changes in NE occurred on the day of diestrus. Unlike the young proestrous rats, but similar to the young diestrous rats, no changes in NE concentrations either in the MPA or in the AN occurred in the old persistently diestrous rats. These data demonstrate that NE concentrations in the MPA and AN change during the estrous cycle. We believe the increase in NE on the afternoon of proestrus is related to the surge in serum luteinizing hormone (LH) that occurs simultaneously in this stage of the estrous cycle. The lack of change in NE conce...Continue Reading

References

Jan 1, 1990·Life Sciences·D L Palazzolo, S K Quadri
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Dec 1, 1967·Endocrinology·F J Stefano, A O Donoso
Jun 1, 1993·Proceedings of the Society for Experimental Biology and Medicine·S ThyagaRajanS K Quadri

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Citations

Feb 28, 2004·Brain Research·Heather K Caldwell, H Elliott Albers
Aug 5, 2005·Steroids·Darrell W Brann, Virendra B Mahesh
Sep 19, 2003·Brain Research Bulletin·Maristela Polachini Martins-AfférriJanete Aparecida Anselmo-Franci
Jan 1, 1997·Brain Research Bulletin·P S MohankumarJ L Voogt
Sep 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hiroko MoriMitsuhiro Kawata
Dec 24, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sheba M J MohanKumarPuliyur S Mohankumar
Apr 20, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Ralph L CooperTammy E Stoker
Dec 24, 2011·Journal of Neuroendocrinology·P BalasubramanianS M J Mohankumar
Dec 3, 2020·AIMS Neuroscience·Hannah P Priyanka, Rahul S Nair

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