Cyclic cidofovir (cHPMPC) prevents congenital cytomegalovirus infection in a guinea pig model

Virology Journal
Mark R SchleissAlistair McGregor

Abstract

Congenital cytomegalovirus (CMV) infection is a major public health problem. Antiviral therapies administered during pregnancy might prevent vertical CMV transmission and disease in newborns, but these agents have not been evaluated in clinical trials. The guinea pig model of congenital CMV infection was therefore used to test the hypothesis that antiviral therapy, using the agent agent cyclic cidofovir (cHPMPC), could prevent congenital CMV infection. Pregnant outbred Hartley guinea pigs were challenged in the early-third trimester with guinea pig CMV (GPCMV) and treated with placebo, or the antiviral agent, cyclic cidofovir. To optimize detection of vertical infection, an enhanced green fluorescent protein (eGFP)-tagged virus was employed. Compared to placebo, cyclic cidofovir-treated dams and pups had reduced mortality following GPCMV challenge. The magnitude of GPCMV-induced maternal and fetal mortality in this study was reduced from 5/25 animals in the placebo group to 0/21 animals in the treatment group (p = 0.05, Fisher's exact test). By viral culture assay, antiviral therapy was found to completely prevent GPCMV transmission to the fetus. In control pups, 5/19 (26%) were culture-positive for GPCMV, compared to 0/16 of p...Continue Reading

References

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Citations

Mar 14, 2007·Virology Journal·Nigel K WoolfFred J Koehrn
Jul 3, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Arianna MareriGiovanni Nigro
Sep 3, 2011·Expert Opinion on Drug Metabolism & Toxicology·Alistair McGregor, K Yeon Choi
Jun 6, 2007·Expert Review of Anti-infective Therapy·Marian G Michaels
Oct 21, 2020·Antimicrobial Agents and Chemotherapy·Stuart T HamiltonWilliam D Rawlinson

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Methods Mentioned

BETA
immunoprecipitation
electrophoresis
fluorescence microscopy
ELISA

Software Mentioned

GraphPad
BLAST
InStat

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Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.