Cyclic combination chemotherapy for metastatic breast cancer: comparison of two CMF schedules

Oncology
S Biran, G Brufman

Abstract

104 nonrandomized patients suffering from metastatic breast cancer were treated with monthly cycles of cyclophosphamide, methotrexate and 5-fluorouracil (CMF). One group (group A, 44 patients) received low-dose CMF and another one (group B, 60 patients) received standard doses. In both cases, therapy was cycled every 29 days. Group A patients had a response rate of 50.7%, including 5 complete remissions. The median duration of response was 8.2 months. For group B patients, the response rate was of 68.1%, including 10 complete remissions. The median duration of response was 10.6 months. Toxicity was greater in group B patients, the main side effects being nausea, vomiting, leukopenia, thrombocytopenia, alopecia and stomatitis.

Citations

Dec 1, 1985·Journal of Steroid Biochemistry·F CavalliK W Brunner
Feb 21, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R K GregoryS Ashley
Apr 1, 1989·Journal of Veterinary Internal Medicine·E J LaingA Baur
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