Cyclic comonomers for the synthesis of carboxylic acid and amine functionalized poly(L-lactic acid)

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Markus Heiny, V Prasad Shastri

Abstract

Degradable aliphatic polyesters such as poly(lactic acid) are widely used in biomedical applications, however, they lack functional moieties along the polymer backbone that are amenable for functionalization reactions or could be the basis for interactions with biological systems. Here we present a straightforward route for the synthesis of functional α-ω epoxyesters as comonomers for lactide polymerization. Salient features of these highly functionalized epoxides are versatility in functionality and a short synthetic route of less than four steps. The α-ω epoxyesters presented serve as a means to introduce carboxylic acid and amine functional groups into poly(lactic acid) polymers via ring-opening copolymerization.

References

Jan 1, 1972·Oral Surgery, Oral Medicine, and Oral Pathology·D E Cutright, E E Hunsuck
Oct 27, 1998·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·K A AthanasiouS S Burkhart
Mar 20, 2001·Journal of Biomedical Materials Research·C M Agrawal, R B Ray
Nov 3, 2004·Cancer Research·Omid C FarokhzadRobert Langer
Dec 9, 2004·Chemical Reviews·Odile Dechy-CabaretDidier Bourissou
Jun 14, 2006·Biomacromolecules·Warren W GerhardtMarcus Weck
Oct 30, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Eric M SussmanV Prasad Shastri
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jin-Wook Yoo, Samir Mitragotri
Jul 6, 2010·Macromolecular Bioscience·Yakai FengAndreas Lendlein
Jun 7, 2011·International Journal of Pharmaceutics·Susanne FredenbergAnders Axelsson
Feb 27, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Julia SchneiderV Prasad Shastri
Jan 13, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pedro Pires Goulart GuimarãesRubén Dario Sinisterra

❮ Previous
Next ❯

Citations

Dec 17, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Takeshi Endo, Atsushi Sudo

❮ Previous
Next ❯

Methods Mentioned

BETA
Nuclear

Software Mentioned

Pyris Manager
TopSpin
WinGPC

Related Concepts

Related Feeds

Bioremediation (ASM)

Bioremediation is the treatment and removal of harmful pollutants or contaminants through the use of microorganisms. Discover the latest research here.

© 2021 Meta ULC. All rights reserved