Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release

Bioorganic & Medicinal Chemistry
Junfeng WangYong-Xian Cheng

Abstract

Investigation of the roots of Myrica nana afforded five new cyclic diarylheptanoids, myricananins A-E (1-5), two new artifacts of myricananins A and B (6-7), and four known compounds, 12-hydroxymyricanone (8), alnusonol (9), myricatomentogenin (10), and actinidione (11). The structures of these new compounds were established by detailed spectroscopic methods. The stereochemistry of compounds 1 and 2 were determined by single-crystal X-ray diffraction. In exception of compounds 2, 6 and 10, all the other compounds were examined for their inhibitory effects on nitric oxide production in lipopolysaccharides-activated macrophages. Compounds 1, 3, 7, 8 and 9 inhibited the release of nitric oxide with IC(50) values of 45.32, 63.51, 52.81, 30.19 and 46.18muM, respectively. Furthermore, compound 1 was found to inhibit the expression of inducible nitric oxide synthase.

References

Aug 12, 2004·Phytotherapy Research : PTR·Marii TakahashiMotoyoshi Satake
Oct 10, 2006·Phytochemistry·Kulsum AraMohammad A Rashid

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Citations

Oct 7, 2011·Journal of Asian Natural Products Research·Jun ZhaoYong-Xian Cheng
Aug 1, 2015·International Journal of Molecular Sciences·Bruno J C SilvaDiana C G A Pinto
Aug 19, 2015·Natural Product Reports·Jamie E SmythPaul A Keller
Jan 22, 2021·The Journal of Organic Chemistry·Paul MasséGilles Hanquet
Dec 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gonçalo P RosaMaria Carmo Barreto
Jan 11, 2021·Bioorganic & Medicinal Chemistry·Corinne Vanucci-Bacqué, Florence Bedos-Belval
Feb 6, 2020·Fitoterapia·De-Juan SunLi-Xia Chen

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