Cyclic flow variations after angioplasty: a rare phenomenon predictive of immediate complications. DEBATE Investigator's Group

American Heart Journal
M SunamuraP W Serruys

Abstract

Experimental studies and studies in human beings have indicated that cyclic flow variation (CFV) is a reliable marker of the formation of platelet aggregates and thus may be predictive of immediate complications after coronary angioplasty. In this study, the incidence and clinical relevance of CFV in a large patient population after elective percutaneous transluminal coronary angioplasty (PTCA) was assessed. One hundred two patients with one-vessel disease and no previous Q-wave myocardial infarction underwent angiographically successful PTCA of a single lesion of a major coronary artery. A Doppler guide wire inserted distal to the stenosis was used to monitor flow velocity continuously after PTCA for 15 minutes. In 94 (92%) of 102 patients, a stable and reliable Doppler signal could be recorded for 15 minutes after the procedure. CFV, defined as gradual decline in flow over several minutes followed by a sudden restoration to higher values, was observed in 4 patients. In 3 of these 4 patients, the occurrence of CFV was predictive of immediate complications (2 intracoronary thrombosis and 1 acute closure), whereas none of the patients without CFV (n = 90) showed acute closure during hospital stay. In conclusion, CFVs in patients...Continue Reading

References

Sep 1, 1992·Journal of the American College of Cardiology·B F WallerJ D Slack
Jan 1, 1991·Journal of the American College of Cardiology·E J EichhornJ T Willerson

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Citations

Aug 18, 2006·Basic Research in Cardiology·Andreas SkyschallyGerd Heusch
Nov 5, 1997·American Heart Journal·B A BergelsonC L Tommaso
Apr 12, 2000·Journal of the American College of Cardiology·L J FeldmanG Steg
Mar 11, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Jan-Julius StampfussArtur-Aron Weber
Mar 26, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Andreas SkyschallyGerd Heusch

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