PMID: 7540093Mar 1, 1995Paper

Cyclic GMP-mediated inhibition of L-type Ca2+ channel activity by human natriuretic peptide in rabbit heart cells

British Journal of Pharmacology
N TohseM Kanno

Abstract

1. Effects of atrial natriuretic peptide (ANP) on the L-type Ca2+ channels were examined in rabbit isolated ventricular cells by use of whole-cell and cell-attached configurations of the patch clamp methods. ANP produced a concentration-dependent decrease (10-100 nM) in amplitude of a basal Ca2+ channel current. 2. The inactive ANP (methionine-oxidized ANP, 30 nM) failed to decrease the current. 3. 8-Bromo-cyclic GMP (300 microM), a potent activator of cyclic GMP-dependent protein kinase (PKG), produced the same effects on the basal Ca2+ channel current as those produced by ANP. The cyclic GMP-induced inhibition of the Ca2+ channel current was still evoked in the presence of 1-isobutyl-3-methyl-xanthine, an inhibitor of phosphodiesterase. ANP failed to produce inhibition of the Ca2+ channel current in the presence of 8-bromo-cyclic GMP. 4. In the single channel recording, ANP and 8-bromo-cyclic GMP also inhibited the activities of the L-type Ca2+ channels. Both agents decreased the open probability (NPo) without affecting the unit amplitude. 5. The present results suggest that ANP inhibits the cardiac L-type Ca2+ channel activity through the intracellular production of cyclic GMP and then activation of PKG.

References

Aug 1, 1992·Pflügers Archiv : European journal of physiology·B Le GrandE Coraboeuf
Oct 1, 1992·Circulation·K J Koller, D V Goeddel
Aug 1, 1991·Circulation Research·N Tohse, N Sperelakis
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P F MéryR Fischmeister
Jun 1, 1991·Pflügers Archiv : European journal of physiology·L H Clapp, A M Gurney
Feb 1, 1990·Pflügers Archiv : European journal of physiology·N TohseM Kanno
Apr 1, 1990·Canadian Journal of Physiology and Pharmacology·G M WahlerN Sperelakis
Feb 1, 1987·Journal of Cardiovascular Pharmacology·L CriscioneK G Hofbauer
Jun 1, 1987·The Journal of Physiology·R Fischmeister, H C Hartzell
Apr 1, 1988·Circulation Research·M P Gisbert, R Fischmeister
Jun 1, 1989·Journal of the American College of Cardiology·S S GottliebM Packer
Jan 1, 1989·Annual Review of Pharmacology and Toxicology·P NeedlemanH E Tolunay
Apr 1, 1989·Pflügers Archiv : European journal of physiology·R C LeviR Fischmeister
Sep 29, 1989·Biochemical and Biophysical Research Communications·L Neyses, H Vetter
Nov 1, 1985·Science·R D WanglerJ E Chimoskey
Oct 1, 1985·The Journal of Clinical Investigation·Y ShenkerR J Grekin
Feb 16, 1988·European Journal of Pharmacology·T X WatanabeM Imai
Apr 1, 1985·Circulation Research·R W LappeR L Wendt
Oct 1, 1982·Pflügers Archiv : European journal of physiology·G Isenberg, U Klockner

❮ Previous
Next ❯

Citations

Jul 1, 1996·Molecular and Cellular Biochemistry·V KecskemetiP Nanasi
Jan 1, 1996·Basic Research in Cardiology·L Hove-MadsenR Fischmeister
Apr 27, 2012·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Ljiljana NikolićBranka Janać
Mar 1, 2006·Progress in Biophysics and Molecular Biology·Fabien BretteLaurent Sallé
Feb 13, 2001·European Journal of Pharmacology·A NirY Hasin
Aug 14, 1999·Progress in Biophysics and Molecular Biology·Y Shimoni
Nov 5, 1999·Hearing Research·M SzönyiP Dallos
Jun 3, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Seyed A GaskariSamuel S Lee
Dec 12, 2001·British Journal of Pharmacology·J F NdisangE Masini
Nov 19, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chiung-yin ChungEmilia Entcheva
Feb 1, 1996·Journal of Cardiovascular Electrophysiology·H F ClemoB S Stambler
Oct 24, 1998·Journal of Cardiovascular Electrophysiology·Y MurakawaM Omata
Jul 10, 2010·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Waleed K Al-Hamoudi
Nov 20, 1998·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·L YanH R Weiss
Nov 20, 1998·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·L YanH R Weiss
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·M JankowskiJ Gutkowska
Jul 13, 2001·Journal of Molecular and Cellular Cardiology·M MishraR Kumar
Nov 16, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mark J Perrin, Michael H Gollob
Dec 25, 2015·Progress in Biophysics and Molecular Biology·Motahareh MoghtadaeiRobert A Rose
Aug 18, 2004·Neurochemistry International·Claudio GrassiGian Battista Azzena
Aug 30, 2002·Biochemical and Biophysical Research Communications·Emanuela MasiniBruno Mondovì
Mar 2, 2010·Journal of Molecular and Cellular Cardiology·Marco MeweChristiane K Bauer
Apr 4, 2017·Journal of Molecular and Cellular Cardiology·Claire Y ZhaoRaimond L Winslow
Jul 12, 2003·The Journal of Biological Chemistry·Nathan AirhartMichael Silberbach
Jul 1, 1997·Circulation Research·D D DoyleE Page
Apr 29, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Hideko InabaYuji Murakawa
May 25, 2012·Journal of Cardiovascular Pharmacology·László DrimbaBarna Peitl
Jul 16, 2014·The Journal of Pharmacology and Experimental Therapeutics·Lise Román MoltzauEirik Qvigstad
Sep 28, 2002·Journal of Cardiovascular Pharmacology·Akira KudohTomoko Takazawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.