Cyclic Hydroxamic Acid Analogues of Bacterial Siderophores as Iron-Complexing Agents prepared through the Castagnoli-Cushman Reaction of Unprotected Oximes

Chemistry : a European Journal
Olga BakulinaMikhail Krasavin

Abstract

The first application of multicomponent chemistry (the Castagnoli-Cushman reaction) toward the convenient one-step preparation of cyclic hydroxamic acids is described. Cyclic hydroxamic acids are close analogues of bacterial siderophores (iron-binding compounds) and form stable complexes with Fe3+ions as confirmed by spectrophotometric measurements. These compounds are potential components for the design of chelating agents for iron overload disease therapy, as well as siderophore-based carrier systems for antibiotic delivery across the bacterial cell wall.

References

Feb 9, 1973·The Journal of Organic Chemistry·M Cushman, N Castagnoli
Dec 29, 2006·The Journal of Antibiotics·Bernd SontagFriedrich G Hansske
Nov 6, 2007·Bioorganic & Medicinal Chemistry Letters·Yue-Mei ZhangPaul F Jackson
Sep 12, 2009·Organic Letters·Ranjan Banerjee, S Bruce King
Sep 3, 2011·Environmental Microbiology·Isabelle J SchalkArmelle Braud
Jun 19, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Ilze MutulePeteris Trapencieris
Jul 19, 2014·The Journal of Organic Chemistry·Jian LiuSpencer Knapp
Aug 12, 2014·Trends in Pharmacological Sciences·Agnieszka GórskaMichał Piotr Marszałł
Mar 13, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Timothy C Johnstone, Elizabeth M Nolan
Aug 1, 2015·Organic Letters·Dmitry Dar'inMikhail Krasavin
Aug 1, 2015·Blood Cells, Molecules & Diseases·Khushnooma ItaliaKanjaksha Ghosh
Dec 26, 2017·Tetrahedron Letters·Daniel PolyakSpencer Knapp

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Citations

May 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elizaveta KarchuganovaMikhail Krasavin
Mar 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Evgeny ChupakhinMikhail Krasavin
Sep 3, 2020·ACS Omega·Mykhailo I AdamovskyiSergey V Ryabukhin
Sep 3, 2021·Chemical Communications : Chem Comm·Zi-Qiong GuoHui-Xiong Dai

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