PMID: 2508986Sep 1, 1989Paper

Cyclic interferon gamma treatment of patients with metastatic renal carcinoma

British Journal of Urology
J W Grups, H G Frohmüller

Abstract

The treatment of metastatic renal carcinoma is still unsatisfactory because of the lack of effective systemic therapy. In 14 patients with metastatic renal carcinoma an attempt was made to influence the course of the disease by administration of recombinant human interferon (rHu-IFN) gamma; 9 patients were evaluated after treatment. There was partial remission in 3 patients, stable disease in 2 and tumour progression in 4. The cyclic application of rHu-IFN at a dose of 0.25 mg/day for 8 days, with treatment-free intervals of 3 to 4 weeks, was tolerated well. Side effects consisted mainly of fever and leucocytopenia. From this small series it seems that cyclic IFN gamma treatment might be helpful in some cases of metastatic renal carcinoma.

References

Aug 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R QuesadaJ U Gutterman

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Citations

Jun 1, 1994·Critical Reviews in Oncology/hematology·K Pittman, P Selby
Sep 29, 2000·Urologic Oncology·J Vuky, R J Motzer
Aug 11, 1995·Science·S MitragotriR Langer
Apr 1, 1994·The Journal of Dermatology·M OnderT Imir

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