Cyclic Lipodepsipeptides From Pseudomonas spp. - Biological Swiss-Army Knives

Frontiers in Microbiology
Niels Geudens, José C Martins

Abstract

Cyclic lipodepsipeptides produced by Pseudomonas spp. (Ps-CLPs) are biosurfactants that constitute a diverse class of versatile bioactive natural compounds with promising application potential. While chemically diverse, they obey a common structural blue-print, allowing the definition of 14 distinct groups with multiple structurally homologous members. In addition to antibacterial and antifungal properties the reported activity profile of Ps-CLPs includes their effect on bacterial motility, biofilm formation, induced defense responses in plants, their insecticidal activity and anti-proliferation effects on human cancer cell-lines. To further validate their status of potential bioactive substances, we assessed the results of 775 biological tests on 51 Ps-CLPs available from literature. From this, a fragmented view emerges. Taken as a group, Ps-CLPs present a broad activity profile. However, reports on individual Ps-CLPs are often much more limited in the scope of organisms that are challenged or activities that are explored. As a result, our analysis shows that the available data is currently too sparse to allow biological function to be correlated to a particular group of Ps-CLPs. Consequently, certain generalizations that appe...Continue Reading

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Citations

Jun 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Niels GeudensJosé C Martins
Aug 23, 2019·Natural Product Reports·Sebastian Götze, Pierre Stallforth
Feb 14, 2020·Organic & Biomolecular Chemistry·Sebastian Götze, Pierre Stallforth
Sep 5, 2020·Critical Reviews in Microbiology·Léa GirardRené De Mot
Oct 6, 2020·Frontiers in Bioengineering and Biotechnology·Jérôme CrouzetStéphan Dorey
Nov 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olumide Owolabi OmoboyeMonica Höfte
Jul 14, 2020·Frontiers in Microbiology·Sofija AndrićMarc Ongena
Dec 12, 2020·Computational and Structural Biotechnology Journal·Antoine Zboralski, Martin Filion
Dec 12, 2020·Frontiers in Plant Science·Jelena Pršić, Marc Ongena
Feb 3, 2021·Proceedings of the National Academy of Sciences of the United States of America·Shuaibing ZhangPierre Stallforth
Oct 10, 2021·Applied Microbiology and Biotechnology·Ana F S da CunhaSona Jain
Nov 4, 2021·Applied and Environmental Microbiology·Léa GirardRené De Mot

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Methods Mentioned

BETA
WLIP

Software Mentioned

NORINE

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