Cyclic movement stimulates hyaluronan secretion into the synovial cavity of rabbit joints.

The Journal of Physiology
K R IngramJ R Levick

Abstract

The novel hypothesis that the secretion of the joint lubricant hyaluronan (HA) is coupled to movement has implications for normal function and osteoarthritis, and was tested in the knee joints of anaesthetized rabbits. After washing out the endogenous synovial fluid HA (miscibility coefficient 0.4), secretion into the joint cavity was measured over 5 h in static joints and in passively cycled joints. The net static secretion rate (11.2 +/- 0.7 microg h(-1), mean +/- s.e.m., n = 90) correlated with the variable endogenous HA mass (mean 367 +/- 8 microg), with a normalized value of 3.4 +/- 0.2 microg h(-1) (100 microg)(-1) . Cyclic joint movement approximately doubled the net HA secretion rate to 22.6 +/- 1.2 microg h(-1) (n = 77) and raised the normalized percentage to 5.9 +/- 0.3 microg h(-1) (100 microg)(-1). Secretion was inhibited by 2-deoxyglucose and iodoacetate, confirming active secretion. The net accumulation rate underestimated true secretion rate due to some trans-synovial loss. HA turnover time (endogenous mass/secretion rate) was 17-30 h (static) to 8-15 h (moved) The results demonstrate for the first time that the active secretion of HA is coupled to joint usage. Movement-secretion coupling may protect joints again...Continue Reading

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Citations

Aug 20, 2010·American Journal of Physiology. Cell Physiology·R J LargeN G McHale
Sep 29, 2011·Journal of Biomechanics·William J McCartyRobert L Sah
Dec 17, 2011·Annals of the New York Academy of Sciences·Daniel J LeongHui B Sun
Aug 10, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Alexander Y HuiRobert L Sah
Oct 1, 2010·Arthritis and Rheumatism·Blandine PouletAndrew A Pitsillides
Jul 8, 2014·Cranio : the Journal of Craniomandibular Practice·Guillermo CasaresCarlos Navarro Vila
Jun 17, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Hemmo A BosscherMiles R Day
Jan 30, 2019·International Journal of Molecular Sciences·Paola CastrogiovanniGiuseppe Musumeci
Mar 18, 2008·The Journal of Physiology·Geraldine Clough
Aug 17, 2021·Journal of Biomechanics·Eben G EstellClark T Hung

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