PMID: 7542935Aug 1, 1995Paper

Cyclic nucleotide-gated channels in visual and olfactory transduction

Biophysical Chemistry
Anna Menini

Abstract

Rod and cone photoreceptors are the light detectors in the visual system whereas olfactory receptor cells are the odorant detectors in the olfactory system. Despite the two very different types of stimuli, light in photoreceptors, and odorant molecules in olfactory receptor cells, the mechanisms of visual and olfactory transduction appear to have many homologies. Both stimuli trigger a chain of enzymatic events that terminates in a change in the concentration of a cyclic nucleotide: a decrease in the concentration of cGMP in photoreceptors, and an increase in the concentration of cAMP in olfactory receptor cells. These cyclic nucleotides directly gate cation channels and therefore a change in their concentration induced by the external stimulus is converted into an electrical signal. The analysis of the ionic selectivity properties of cyclic nucleotidegated channels in retinal rods, cones and in olfactory receptor cells shows that there are many similarities between these channels. They do not appreciably select between alkali monovalent cations and can be permeated and blocked by divalent cations. Their ionic permeation properties are consistent with the presence of a cation-binding site of high-field strength in the pore.

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Citations

Oct 18, 2003·Insect Biochemistry and Molecular Biology·Günter GisselmannHanns Hatt
Feb 1, 1996·The Journal of General Physiology·E N Pugh
Aug 1, 1997·The Journal of General Physiology·S H Thompson
Dec 1, 2000·The Journal of General Physiology·J I CraryA L Zimmerman
Jan 1, 2003·The Journal of General Physiology·Miguel Holmgren
May 30, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dylan M DeanAnita L Zimmerman
Apr 25, 2006·FEBS Letters·Simone PifferiAnna Menini
Jul 3, 2007·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Zhengchao WangFangxiong Shi
Apr 23, 2005·The European Journal of Neuroscience·Günter GisselmannHanns Hatt
Dec 24, 2002·Biophysical Journal·Monica MazzoliniVincent Torre
Jan 16, 2015·PloS One·Ninthujah KanageswaranGünter Gisselmann
Dec 1, 1996·The American Journal of Physiology·L C Santy, G Guidotti
Jan 7, 2021·Cell and Tissue Research·Claudia Lodovichi
Oct 1, 1996·Molecular and Cellular Biology·H MischakW Kolch
Oct 25, 2003·Brain Research·Yoji YoshimiMasahiko Ikekita

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