Feb 1, 1983

Cyclic nucleotides and calcium: their role in the control of cell communication in the heart

Cell Biology International Reports
E Estapé-Wainwright, W C De Mello

Abstract

The effects of theophylline and di-butyryl cyclic adenosine 3',5'-monophosphate (db-cAMP) on the electrical coupling of heart cells were investigated in rat trabeculae. Theophylline (4 X 10(-4) M) and db-cAMP (5 X 10(-5) M) increased both the space constant and conduction velocity. The time constant of the membrane was not changed by either drug. Measurements of the time constant of the foot of the action potential and conduction velocity were used to calculate the intracellular longitudinal resistance. Both theophylline and db-cAMP were found to enhance cell-to-cell communication in the heart by decreasing the intracellular longitudinal resistance.

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Mentioned in this Paper

Calcium [EPC]
Adenosine
Calcium
Protoplasm
Resting Potentials
August Rats
Action Potentials
Myocardium
Cell Communication
Electric Conductivity

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