Cyclic nucleotides and central cardiovascular control in the conscious cat

European Journal of Pharmacology
P J ClipshamR H Poyser

Abstract

When infused into the third ventricle of the brain of the conscious cat, the phosphodiesterase inhibitors, papaverine and aminophylline, increased blood pressure and heart rate whilst the phosphodiesterase stimulator, imidazole-4'-acetic acid, decreased blood pressure. Administered intravenously, these compounds caused the opposite effects indicating that the responses after third-ventricular administration were centrally mediated. Infused of dibutyryl cyclic 3',5'-AMP into the third ventricle increased blood pressure and heart rate, whereas dibutyryl cyclic 3',5'-GMP had little effect and antagonised and pressor response to dibutyryl cyclic 3',5'-AMP. ATP, 5'-AMP and adenosine induced similar changes to dibutyryl cyclic 3',5'-AMP, although the pressor responses to these compounds were of different onset and/or duration. When administered into the third ventricle both alpha- and beta-adrenoceptor blocking agents reduced the pressor response caused caused by the phosphodiesterase inhibitor, papaverine, given by the same route. These results demonstrate a central effect of adenosine and adenosine nucleotides to raise blood pressure. The possibility of a specific role for cyclic 3',5'-AMP in the central control of blood pressure i...Continue Reading

References

Jul 1, 1977·Clinical and Experimental Pharmacology & Physiology·B DelbarreH Schmitt
Oct 15, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·A Walland
Jan 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·A Walland
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Jan 1, 1973·Progress in Neurobiology·G I Drummond
Feb 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·C DaltonW Schallek

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Citations

May 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·P Schuhmacher, A Walland
Aug 5, 1983·European Journal of Pharmacology·J D JohnsonG E Isom
Oct 29, 1998·General Pharmacology·G Tunnicliff
Aug 29, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L HultinE Lindström
Nov 3, 2010·The Journal of Pharmacology and Experimental Therapeutics·Xiao-Ming GuanMarc L Reitman

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