Cyclic Octamer Peptoids: Simplified Isosters of Bioactive Fungal Cyclodepsipeptides

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Assunta D'AmatoF De Riccardis

Abstract

Cyclic peptoids have recently emerged as an important class of bioactive scaffolds with unique conformational properties and excellent metabolic stabilities. In this paper, we describe the design and synthesis of novel cyclic octamer peptoids as simplified isosters of mycotoxin depsipeptides bassianolide, verticilide A1, PF1022A and PF1022B. We also examine their complexing abilities in the presence of sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate (TFPB) salt and explore their general insecticidal activity. Finally, we discuss the possible relationship between structural features of free and Na⁺-complexed cyclic octamer peptoids and bioactivities in light of conformational isomerism, a crucial factor affecting cyclic peptoids' biomimetic potentials.

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Citations

Jan 6, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudine Nicole HerlanStefan Bräse
Jul 25, 2019·The Journal of Organic Chemistry·Assunta D'AmatoFrancesco De Riccardis
Sep 19, 2018·The Journal of Organic Chemistry·Rosaria SchettiniFrancesco De Riccardis

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Methods Mentioned

BETA
column chromatography
NMR
acylation

Software Mentioned

Xcalibur

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