Cyclic Peptides that Govern Signal Transduction Pathways: From Prokaryotes to Multi-Cellular Organisms

Current Topics in Medicinal Chemistry
Ryan W MullYftah Tal-Gan

Abstract

Cyclic peptide scaffolds are key components of signal transduction pathways in both prokaryotic and eukaryotic organisms since they act as chemical messengers that activate or inhibit specific cognate receptors. In prokaryotic organisms these peptides are utilized in non-essential pathways, such as quorum sensing, that are responsible for virulence and pathogenicity. In the more evolved eukaryotic systems, cyclic peptide hormones play a key role in the regulation of the overall function of multicellular organisms, mainly through the endocrine system. This review will highlight several prokaryote and eukaryote systems that use cyclic peptides as their primary signals and the potential associated with utilizing these scaffolds for the discovery of novel therapeutics for a wide range of diseases and illnesses.

Citations

Jan 10, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yifang YangYftah Tal-Gan
Sep 12, 2020·Organic & Biomolecular Chemistry·Dominic N McBrayerYftah Tal-Gan
Jan 17, 2019·Chembiochem : a European Journal of Chemical Biology·Christopher M ScheidlerSabine Schneider
Jan 12, 2021·Chemical Reviews·Jovan DamjanovicYu-Shan Lin
Feb 26, 2021·Dose-response : a Publication of International Hormesis Society·Samina RoohiSyed Ali Raza Naqvi

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