Cyclic perylene diimide: Selective ligand for tetraplex DNA binding over double stranded DNA

Bioorganic & Medicinal Chemistry
Suresh VasimallaShigeori Takenaka

Abstract

Synthesized cyclic perylene diimide, cPDI, showed the binding constant of 6.3 × 106 M-1 with binding number of n = 2 with TA-core as a tetraplex DNA in 50 mM Tris-HCl buffer (pH = 7.4) containing 100 mM KCl using Schatchard analysis and showed a higher preference for tetraplex DNA than for double stranded DNA with over 103 times. CD spectra showed that TA-core induced its antiparallel conformation upon addition of cPDI in the absence or presence of K+ or Na+ ions. The cPDI inhibits the telomerase activity with IC50 of 0.3 µM using TRAP assay which is potential anti-cancer drug with low side effect.

Citations

Nov 5, 2019·Chemistry : a European Journal·Shuma KaneyoshiShigeori Takenaka
May 21, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Francesca MaciiTarita Biver
Aug 25, 2020·Chemistry of Heterocyclic Compounds·Andrey M ZhirovIvan V Borovlev

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