Cyclic progestin administration increases energy expenditure and decreases body fat mass in perimenopausal women

Menopause : the Journal of the North American Menopause Society
Angelo CagnacciAnnibale Volpe

Abstract

The menopause transition is characterized by luteal phase defect anovulatory cycles, and changes in body weight and body composition. Resting metabolic rate (RMR) is increased in the luteal phase of the menstrual cycle. We evaluated whether progestin administration increases RMR and influences body composition of perimenopausal women. Thirty-six perimenopausal women were randomly allocated to receive either calcium (1 g/day) continuously plus the progestin nomegestrol acetate (NOMAc; 5 mg/day for 10 days x month for 12 months) or calcium alone. Body composition, RMR, energy intake, and climacteric and psychological symptoms were evaluated at baseline and after 12 months. In the NOMAc group, body composition and RMR analyses were performed twice during the first month of treatment. One evaluation was performed after almost 8 days of NOMAc adjunct, and an another before or almost 15 days after NOMAc administration. Resting metabolic rate was increased by NOMAc administration of 54.5 +/- 73.8 kcal/24 h (P < 0.01). In women treated with NOMAc, fat mass decreased by 1.2 +/- 0.6 kg (P < 0.001). In comparison with controls, body weight (P < 0.05) and body mass index (P < 0.05) were also reduced after 12 months of therapy with NOMAc. I...Continue Reading

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Citations

Apr 29, 2006·Menopause : the Journal of the North American Menopause Society·Lubna Pal
May 18, 2007·Menopause : the Journal of the North American Menopause Society·Cynthia A Stuenkel
Nov 13, 2008·Menopause : the Journal of the North American Menopause Society·Allison Bailey
Jun 12, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Giovanni GrandiAngelo Cagnacci
Feb 24, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Anna Maria PaolettiGian Benedetto Melis
Oct 3, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Kavoos NazeriGoran Samsioe
Sep 16, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Anna Maria PaolettiAngelo Cagnacci
Aug 26, 2015·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Antonella NapolitanoAngelo Cagnacci
May 8, 2007·Fertility and Sterility·Angelo CagnacciAnnibale Volpe
May 8, 2008·American Journal of Human Biology : the Official Journal of the Human Biology Council·Andrew W Froehle
Nov 22, 2008·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J C LovejoyUNKNOWN Stock Conference 2008 Working Group
May 10, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Manuela NeriAnna Maria Paoletti
Nov 2, 2018·Climacteric : the Journal of the International Menopause Society·Y DengA Sun

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