Dec 27, 2018

Cyclic Strain Affects Macrophage Cytokine Secretion and Extracellular Matrix Turnover in Electrospun Scaffolds

Tissue Engineering. Part a
Valentina BonitoAnthal I P M Smits

Abstract

Electrospun elastomeric scaffolds are being used for a variety of in situ tissue engineering applications, in which biomechanical loads play a dominant in vivo role, such as cardiovascular replacements (e.g., heart valve and blood vessel prostheses) and pelvic floor reconstruction. The findings of this study underline that immunomodulatory scaffolds for biomechanically loaded applications should be mechanically tailored, for example, in terms of stiffness and compliance, to support a desirable proregenerative macrophage phenotype. Moreover, this research contributes to the general understanding of pathophysiological macrophage phenotypes in cyclically strained tissues (e.g., atherosclerotic plaques), and their role in tissue regeneration and degeneration.

  • References50
  • Citations3

References

Mentioned in this Paper

Study
In Vivo
Research
Cyclic Peptides
Acellular Membrane
Plaque, Atherosclerotic
Reconstructive Surgical Procedures
Extracellular Matrix
Environment
Tissue Regeneration

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