PMID: 7529542Dec 1, 1994Paper

Cyclic thrombocytopenia associated with IgM anti-GPIIb-IIIa autoantibodies

British Journal of Haematology
Satoru KosugiY Matsuzawa

Abstract

We studied a female patient with cyclic fluctuation in platelet count following splenectomy for autoimmune thrombocytopenia. The cyclical fluctuation appeared to be in phase with her menstrual cycle and her platelet count was low during menses. Bone marrow examinations performed at the peak as well as the bottom of the platelet count showed normal or increased numbers of megakaryocytes. The patient's platelet count increased rapidly after intravenous gamma-globulin (IVIgG) therapy, suggesting that a failure of platelet production is unlikely to account for the cycle. Platelet-associated IgM (PAIgM) was markedly elevated, whereas PAIgG was normal at any stage of the cycle. MACE assay demonstrated that PAIgM contained IgM anti-glycoprotein (GP) IIb-IIIa autoantibodies. Comparison between MACE assay using untreated and EDTA-treated platelets at 37 degrees C demonstrated that the platelet-associated IgM autoantibodies mainly recognized divalent cation-dependent conformation(s) of GPIIb-IIIa. No antibodies were, however, detected in her serum. The levels of IgM anti-GPIIb-IIIa showed an inverse relationship with the platelet count. In spite of the marked increase in platelet count after IVIgG, however, the levels of IgM anti-GPIIb-I...Continue Reading

References

Feb 1, 1991·American Journal of Hematology·R RochaW J Harrington
Mar 1, 1991·British Journal of Haematology·K DanT Nomura
Apr 1, 1989·British Journal of Haematology·A TomerL A Harker
Apr 1, 1985·The Journal of Clinical Investigation·D B CinesA D Schreiber
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Jun 1, 1980·British Journal of Haematology·A E von dem BorneC P Engelfriet
Dec 1, 1993·British Journal of Haematology·C L BalduiniE Ascari

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Citations

May 27, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Melody SauerbornHuub Schellekens
Dec 2, 2004·Blood Reviews·Ronald S Go
Apr 10, 2017·Journal of Mathematical Biology·Gabriel P LangloisLiangliang Wang
Oct 26, 1999·Pediatrics International : Official Journal of the Japan Pediatric Society·H FuruyamaY Ishikawa
Nov 30, 2018·Journal of Theoretical Biology·Changjing ZhugeJinzhi Lei
Nov 17, 2020·Blood·Paul A Kyrle, Sabine Eichinger

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