Cyclic vomiting syndrome: a case series and review of the literature

Frontline Gastroenterology
Jessica ShearerAlexander C Ford

Abstract

Cyclic vomiting syndrome (CVS) is under-recognised. Treatment is difficult as the pathophysiology is incompletely understood. We report our experience of treating patients with amitriptyline, and review the literature to summarise symptoms and associated features, epidemiology, potential pathophysiological mechanisms, differential diagnoses and treatment. Consecutive adult patients with CVS were identified during a 5-year period from January 2010 until December 2015. Medical records were reviewed retrospectively, and age and sex of the patient, symptoms, associated features and response to treatment with amitriptyline were recorded. A luminal gastroenterology clinic at a teaching hospital. Seventeen patients were identified (mean age 29.8 years, 13 (76.5%) female). Five had a history of cannabis use. Duration of symptoms prior to diagnosis ranged from 5 months to 15 years. Fourteen patients commenced amitriptyline, and in eight (57.1%) symptoms either ceased entirely or improved. Review of the literature suggested the prevalence of CVS was 0.5%. Symptoms are stereotypical, with acute episodes of nausea and vomiting, interspersed by periods when the patient is symptom-free. Proposed pathophysiologies include neuroendocrine dysfu...Continue Reading

References

Dec 1, 1988·Mayo Clinic Proceedings·T L AbellJ R Malagelada
Nov 1, 1995·Journal of Pediatric Gastroenterology and Nutrition·I Abu-Arafeh, G Russell
Sep 17, 1998·Pediatrics·B U LiJ R Hayes
Jan 20, 1999·Alimentary Pharmacology & Therapeutics·R W McCallumM W Plankey
Oct 16, 1999·The American Journal of Gastroenterology·C Prakash, R E Clouse
Mar 31, 2001·The American Journal of Gastroenterology·C PrakashR E Clouse
Feb 28, 2002·The Journal of Pharmacology and Experimental Therapeutics·Steven C StoutCharles B Nemeroff
May 24, 2003·Brain : a Journal of Neurology·Leslie Iversen
Jan 12, 2005·American Journal of Medical Genetics. Part a·Richard G BolesB U K Li
Jun 14, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael CamilleriDennis A Revicki
May 9, 2006·Gastroenterology·Jan TackVincenzo Stanghellini
Dec 13, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ray E ClouseChandra Prakash
Feb 16, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F NaminR McCallum
Sep 1, 2007·Current Treatment Options in Gastroenterology·Pavan ChepyalaKevin W Olden
Dec 12, 2007·The American Journal of Gastroenterology·Emer FitzpatrickMarion Rowland
Mar 29, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T L AbellN Vakil
Mar 29, 2008·The American Journal of Gastroenterology·Alexander C FordPaul Moayyedi
May 6, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Pavan Chepyala, Kevin W Olden
Jul 9, 2008·Scandinavian Journal of Gastroenterology·Christopher J ChristensenThomas L Abell
Feb 18, 2009·Cephalalgia : an International Journal of Headache·E A ZakiR G Boles
Mar 18, 2009·World Journal of Gastroenterology : WJG·Siva P SontineniStephen J Lanspa
Aug 29, 2009·Digestive Diseases and Sciences·Reza A HejaziRichard W McCallum
Nov 17, 2009·Journal of General Internal Medicine·Monika KowalczykLawrence Ward
Dec 23, 2009·Journal of Clinical Gastroenterology·Reza A HejaziRichard W McCallum
Feb 26, 2010·BMC Emergency Medicine·Thangam VenkatesanB U K Li
Jun 8, 2010·Journal of Tropical Pediatrics·Niranga Manjuri DevanarayanaShaman Rajindrajith
Jul 30, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T VenkatesanS Jaradeh
Aug 21, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R A HejaziR W McCallum
Dec 15, 2010·Cephalalgia : an International Journal of Headache·Toshiyuki HikitaAkira Kikuchi
Feb 18, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R A HejaziR W McCallum
Jun 15, 2011·Alimentary Pharmacology & Therapeutics·R A Hejazi, R W McCallum
Dec 14, 2011·Current Drug Abuse Reviews·Jonathan A GalliFrank K Friedenberg
Feb 7, 2012·Mayo Clinic Proceedings·Douglas A SimonettoJason H Szostek
May 29, 2012·European Journal of Gastroenterology & Hepatology·Lennard Y W LeeSimon Anderson
Oct 17, 2013·Journal of General Internal Medicine·Mahesh K VidulaLyle L Berkowitz
Nov 5, 2013·European Journal of Pharmacology·Keith A SharkeyLinda A Parker
Feb 6, 2014·The American Journal of Gastroenterology·Toshikatsu OkumuraTsukasa Nozu
Mar 29, 2014·Clinical Medicine & Research·Corina L Iacopetti, Clifford D Packer

❮ Previous
Next ❯

Citations

Mar 31, 2018·Current Opinion in Neurology·Amy A Gelfand
Feb 28, 2018·Frontline Gastroenterology·Anton V Emmanuel
Oct 27, 2018·Current Treatment Options in Gastroenterology·Elliot S YuThangam Venkatesan
Jun 27, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Thangam VenkatesanB U K Li
Nov 24, 2020·Frontiers in Neurology·Umberto RaucciPasquale Parisi
Jul 17, 2021·Clinical Case Reports·S M Yasir ArafatIrin Perveen
Aug 1, 2021·Alimentary Pharmacology & Therapeutics·Vikram Rangan, Anthony J Lembo
Nov 20, 2020·European Journal of Gastroenterology & Hepatology·Abhilash Perisetti, Hemant Goyal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.