PMID: 9168366May 1, 1997Paper

Cyclic vs continuous enteral feeding with omega-3 and gamma-linolenic fatty acids: effects on modulation of phospholipid fatty acids in rat lung and liver immune cells

JPEN. Journal of Parenteral and Enteral Nutrition
John PalomboB R Bistrian

Abstract

Arachidonic acid (AA) present in lung and liver immune cell phospholipids is the precursor of eicosanoids that promote neutrophil margination, leading to tissue injury and inflammation. Administration of novel enteral formulations low in linoleic acid (LA) and containing eicosapentaenoic acid (EPA) from fish oil and gamma-linolenic acid (GLA) from borage oil displaces AA and promotes cell formation of eicosanoids with reduced inflammatory potential. The present study was undertaken to determine whether or not short-term provision of enteral diets containing GLA, EPA, or both in a cyclic fashion modulated the fatty acid composition of rat alveolar macrophage (AM) and liver Kupffer and endothelial (K&E) cell phospholipids in vivo to the extent achieved during continuous feeding. Rats were isocalorically fed through a gastrostomy catheter for 3 or 6 days with high-fat, low-carbohydrate diets that were enriched with either LA (diet A), EPA (diet B), or EPA + GLA (diet C). The rats were randomized by infusion modality, ie, continuous vs cyclic (14 hours feeding with 10 hours fasting daily) feeding. AM and K&E were isolated and phospholipid fatty acid profiles were determined by gas chromatography. The dietary effects on AM and K&E c...Continue Reading

References

May 1, 1979·JPEN. Journal of Parenteral and Enteral Nutrition·E A MascioliG L Blackburn
Feb 1, 1989·The American Journal of Clinical Nutrition·E A MascioliG L Blackburn
Jul 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·P Beau, J Labat
Nov 1, 1994·The American Journal of Clinical Nutrition·S D PhinneyR T Holman
Feb 1, 1993·The Journal of Clinical Investigation·R I SperlingD R Robinson

❮ Previous
Next ❯

Citations

Mar 1, 2012·The Proceedings of the Nutrition Society·Philip C Calder
Mar 20, 2002·The British Journal of Nutrition·D L WaitzbergRémy Meier
Jun 11, 2011·Critical Care : the Official Journal of the Critical Care Forum·Alessandro Pontes-ArrudaUNKNOWN Investigating Nutritional Therapy with EPA, GLA and Antioxidants Role in Sepsis Treatment (INTERSEPT) Study Group
Mar 1, 2010·Nutrients·Philip C Calder
Aug 28, 2010·Nutrition Reviews·Julie M Martin, Renee D Stapleton
Aug 6, 2011·European Journal of Pharmacology·Philip C Calder
Jan 10, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Theresa MayesRichard J Kagan
Jul 13, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·F RoseU Sibelius
Dec 17, 2002·Chemical Research in Toxicology·Chen-Chen Lee, Jaw-Jou Kang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.